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Int. J. Mol. Sci. 2015, 16(2), 2626-2640; doi:10.3390/ijms16022626

Fatal Attraction: How Bacterial Adhesins Affect Host Signaling and What We Can Learn from Them

Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
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Author to whom correspondence should be addressed.
Academic Editor: Charles A. Collyer
Received: 27 November 2014 / Revised: 25 December 2014 / Accepted: 19 January 2015 / Published: 23 January 2015
(This article belongs to the Special Issue Bioactive Carbohydrates and Peptides)
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Abstract

The ability of bacterial species to colonize and infect host organisms is critically dependent upon their capacity to adhere to cellular surfaces of the host. Adherence to cell surfaces is known to be essential for the activation and delivery of certain virulence factors, but can also directly affect host cell signaling to aid bacterial spread and survival. In this review we will discuss the recent advances in the field of bacterial adhesion, how we are beginning to unravel the effects adhesins have on host cell signaling, and how these changes aid the bacteria in terms of their survival and evasion of immune responses. Finally, we will highlight how the exploitation of bacterial adhesins may provide new therapeutic avenues for the treatment of a wide range of bacterial infections. View Full-Text
Keywords: adhesion; adhesin; cell-signaling; host–pathogen interaction; bacterial attachment; anti-adhesion therapy adhesion; adhesin; cell-signaling; host–pathogen interaction; bacterial attachment; anti-adhesion therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Stones, D.H.; Krachler, A.-M. Fatal Attraction: How Bacterial Adhesins Affect Host Signaling and What We Can Learn from Them. Int. J. Mol. Sci. 2015, 16, 2626-2640.

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