Special Issue "Biological Applications of Magnetic Nanoparticles"

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: 20 December 2017

Special Issue Editor

Guest Editor
Prof. Dr. Yurii K. Gun'ko

School of Chemistry, Trinity College Dublin, Dublin 2, Ireland
Website | E-Mail
Interests: quantum dots; magnetic nanomaterials; carbon nanomaterials; nano-bio-technology; biological imaging

Special Issue Information

Dear Colleagues,

Magnetic nanomaterials represent one of the most important and emerging classes of materials in nanotechnology due to a range of potential applications, including magnetic data storage, catalysis, magnetic separation, sensing, waste water treatment, and many others. In particular, magnetic nanoparticles have been envisaged for various biological and biomedical applications. For example, magnetic nanoparticles can be used as drug delivery agents, which can be localized in the body at a site of interest using an external magnetic field. When exposed to an alternating magnetic field, magnetic nanoparticles can serve as powerful heat sources, destroying tumour cells, that allows to use these nanomaterials in cancer hyperthermia therapy. Magnetic fluids based on aqueous dispersions of small size magnetic nanoparticles have also been utilized as contrast agents for magnetic resonance imaging (MRI). This Special Issue is focused on the preparation, biological behaviour studies and prospective applications of magnetic nanomaterials in biology and medicine.

Prof. Yurii Gun'ko
Guest Editor

Manuscript Submission Information

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Keywords

  • Magnetic nanoparticles
  • drug delivery
  • sensing
  • nanomedicine
  • MRI
  • magnetic hyperthermia

Published Papers (3 papers)

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Research

Open AccessArticle Investigating the Role of Shell Thickness and Field Cooling on Saturation Magnetization and Its Temperature Dependence in Fe3O4/γ-Fe2O3 Core/Shell Nanoparticles
Appl. Sci. 2017, 7(12), 1269; doi:10.3390/app7121269
Received: 31 October 2017 / Revised: 15 November 2017 / Accepted: 21 November 2017 / Published: 5 December 2017
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Abstract
Understanding saturation magnetization and its behavior with particle size and temperature are essential for medical applications such magnetic hyperthermia. We report the effect of shell thickness and field cooling on the saturation magnetization and its behavior with temperature in Fe3O4
[...] Read more.
Understanding saturation magnetization and its behavior with particle size and temperature are essential for medical applications such magnetic hyperthermia. We report the effect of shell thickness and field cooling on the saturation magnetization and its behavior with temperature in Fe3O4/γ-Fe2O3 core/shell nanoparticles of fixed core diameter (8 nm) and several shell thicknesses. X-ray diffraction (XRD) analysis and transmission electron microscopy (TEM, high-resolution transmission electron microscopy (HRTEM)) were used to investigate the phase and the morphology of the samples. Selected area electron diffraction (SAED) confirmed the core/shell structure and phases. Using a SQUID (San Diego, CA, USA), magnetic measurements were conducted in the temperature range of 2 to 300 K both under zero field-cooling (ZFC) and field-cooling (FC) protocols at several field-cooling values. In the ZFC state, considerable enhancement of saturation magnetization was obtained with the increase of shell thickness. After field cooling, we observed a drastic enhancement of the saturation magnetization in one sample up to 120 emu/g (50% larger than the bulk value). In both the FC and ZFC states, considerable deviations from the original Bloch’s law were observed. These results are discussed and attributed to the existence of interface spin-glass clusters which are modified by the changes in the shell thickness and the field-cooling. Full article
(This article belongs to the Special Issue Biological Applications of Magnetic Nanoparticles)
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Open AccessFeature PaperArticle Targeted Molecular Imaging of Pancreatic Cancer with a Miniature Endoscope
Appl. Sci. 2017, 7(12), 1241; doi:10.3390/app7121241
Received: 10 October 2017 / Revised: 27 November 2017 / Accepted: 28 November 2017 / Published: 30 November 2017
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Abstract
It is highly desirable to develop novel approaches to improve patient survival rate of pancreatic cancer through early detection. Here, we present such an approach based on photoacoustic and fluorescence molecular imaging of pancreatic tumor using a miniature multimodal endoscope in combination with
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It is highly desirable to develop novel approaches to improve patient survival rate of pancreatic cancer through early detection. Here, we present such an approach based on photoacoustic and fluorescence molecular imaging of pancreatic tumor using a miniature multimodal endoscope in combination with targeted multifunctional iron oxide nanoparticles (IONPs). A novel fan-shaped scanning mechanism was developed to minimize the invasiveness for endoscopic imaging of pancreatic tumors. The results show that the enhancements in photoacoustic and fluorescence signals using amino-terminal fragment (ATF) targeted IONPs were ~four to six times higher compared to that using non-targeted IONPs. Our study indicates the potential of the combination of the multimodal photoacoustic-fluorescence endoscopy and targeted multifunctional nanoparticles as an efficient tool to provide improved specificity and sensitivity for pancreatic cancer detection. Full article
(This article belongs to the Special Issue Biological Applications of Magnetic Nanoparticles)
Figures

Figure 1

Open AccessArticle A Fast and Cost-Effective Detection of Melamine by Surface Enhanced Raman Spectroscopy Using a Novel Hydrogen Bonding-Assisted Supramolecular Matrix and Gold-Coated Magnetic Nanoparticles
Appl. Sci. 2017, 7(5), 475; doi:10.3390/app7050475
Received: 8 March 2017 / Revised: 27 April 2017 / Accepted: 27 April 2017 / Published: 3 May 2017
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Abstract
A fast and cost-effective melamine detection approach has been developed based on surface enhanced Raman spectroscopy (SERS) using a novel hydrogen bonding-assisted supramolecular matrix. The detection utilizes Fe3O4/Au magnetic nanoparticles coated with 5-aminoorotic acid (AOA) as a SERS active
[...] Read more.
A fast and cost-effective melamine detection approach has been developed based on surface enhanced Raman spectroscopy (SERS) using a novel hydrogen bonding-assisted supramolecular matrix. The detection utilizes Fe3O4/Au magnetic nanoparticles coated with 5-aminoorotic acid (AOA) as a SERS active substrate (Fe3O4/Au–AOA), and Rhodamine B (RhB) conjugated AOA as a Raman reporter (AOA–RhB). Upon mixing the reagents with melamine, a supramolecular complex [Fe3O4/Au–AOA•••melamine•••AOA–RhB] was formed due to the strong multiple hydrogen bonding interactions between AOA and melamine. The complex was separated and concentrated to a pellet by an external magnet and used as a supramolecular matrix for the melamine detection. Laser excitation of the complex pellet produced a strong SERS signal diagnostic for RhB. The logarithmic intensity of the characteristic RhB peaks was found to be proportional to the concentration of melamine with a limit of detection of 2.5 µg/mL and a detection linearity range of 2.5~15.0 µg/mL in milk. As Fe3O4 nanoparticles and AOA are thousands of times less expensive than the monoclonal antibody used in a traditional sandwich immunoassay, the current assay drastically cut down the cost of melamine detection. The current approach affords promise as a biosensor platform that cuts down sample pre-treatment steps and measurement expense. Full article
(This article belongs to the Special Issue Biological Applications of Magnetic Nanoparticles)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Minimally invasive molecular imaging of pancreatic cancer with a miniature multimodal endoscope

Authors: Xianjin Dai, Weiping Qian, Lily Yang, Huabei Jiang

Multimodal magnetic nanoparticles for biological applications

Authors: R. Serrano Garcia, S. Stafford and Y.K. Gun'ko

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