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Appl. Sci. 2017, 7(12), 1241; https://doi.org/10.3390/app7121241

Targeted Molecular Imaging of Pancreatic Cancer with a Miniature Endoscope

1
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
2
Departments of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA
3
Department of Medical Engineering, University of South Florida, Tampa, FL 33620, USA
4
Departments of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
*
Author to whom correspondence should be addressed.
Received: 10 October 2017 / Revised: 27 November 2017 / Accepted: 28 November 2017 / Published: 30 November 2017
(This article belongs to the Special Issue Biological Applications of Magnetic Nanoparticles)
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Abstract

It is highly desirable to develop novel approaches to improve patient survival rate of pancreatic cancer through early detection. Here, we present such an approach based on photoacoustic and fluorescence molecular imaging of pancreatic tumor using a miniature multimodal endoscope in combination with targeted multifunctional iron oxide nanoparticles (IONPs). A novel fan-shaped scanning mechanism was developed to minimize the invasiveness for endoscopic imaging of pancreatic tumors. The results show that the enhancements in photoacoustic and fluorescence signals using amino-terminal fragment (ATF) targeted IONPs were ~four to six times higher compared to that using non-targeted IONPs. Our study indicates the potential of the combination of the multimodal photoacoustic-fluorescence endoscopy and targeted multifunctional nanoparticles as an efficient tool to provide improved specificity and sensitivity for pancreatic cancer detection. View Full-Text
Keywords: photoacoustic imaging; fluorescence imaging; multifunctional nanoparticles; pancreatic cancer; molecular imaging; multimodal endoscopy photoacoustic imaging; fluorescence imaging; multifunctional nanoparticles; pancreatic cancer; molecular imaging; multimodal endoscopy
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Dai, X.; Qian, W.; Yang, H.; Yang, L.; Jiang, H. Targeted Molecular Imaging of Pancreatic Cancer with a Miniature Endoscope. Appl. Sci. 2017, 7, 1241.

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