Table of Contents
Molecules, Volume 22, Issue 10 (October 2017)
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Cover Story (view full-size image) Isolation and purification of low molecular weight proteins and peptides (potential biomarkers) [...] Read more. Isolation and purification of low molecular weight proteins and peptides (potential biomarkers) from biological fluids is a challenging task, since these are in very low concentration, susceptible to protease degradation and often masked by abundant proteins. Herein, novel core–shell silica nanoparticles were synthesized, and evaluated with both high and low molecular weight (LMW) model proteins/peptides. Nanoparticles hindered the entrance of high molecular weight proteins due to restrictive pores in the polymeric shell, while LMW proteins/peptides were captured by interaction with the molecular bait immobilized in the core. View this paper