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Molecules 2017, 22(10), 1699; doi:10.3390/molecules22101699

Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements

1
Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
2
Department of Pharmacy, University of Swabi, Swabi 23340, Pakistan
3
Department of Microbiology, Sardar Bahdur Khan Women University, Quetta 87300, Pakistan
4
Department of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
5
Department of Pharmacy, University of Lahore, Lahore 54000, Pakistan
6
Department of Biotechnology, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
*
Author to whom correspondence should be addressed.
Received: 12 September 2017 / Revised: 30 September 2017 / Accepted: 2 October 2017 / Published: 21 October 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [858 KB, uploaded 21 October 2017]   |  

Abstract

In herbalism, botanical supplements are commonly believed to be safe remedies, however, botanical supplements and dietary ingredients interact with transport and metabolic processes, affecting drug disposition. Although a large number of studies have described that botanical supplements interfere with drug metabolism, the mode of their interaction with drug transport processes is not well described. Such interactions may result in serious undesired effects and changed drug efficacy, therefore, some studies on interaction between botanical supplement ingredients and drug transporters such as P-gp and OATPs are described here, suggesting that the interaction between botanical supplements and the drug transporters is clinically significant. View Full-Text
Keywords: botanical supplements; metabolism; drug transporters; P-glycoproteins; organic anion transporting polypeptides botanical supplements; metabolism; drug transporters; P-glycoproteins; organic anion transporting polypeptides
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Murtaza, G.; Ullah, N.; Mukhtar, F.; Nawazish, S.; Muneer, S.; Mariam. Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements. Molecules 2017, 22, 1699.

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