New Triterpenoid Saponins from the Herb Hylomecon japonica
AbstractBackground: Hylomecon japonica, a plant of the Papaveraceae family which is well-known for the alkaloids they produce, is a perennial plant widely distributed in the northeast, central and east regions of China. Although a variety of chemical constituents, including alkaloids, flavonoids, and megastigmoids, have been isolated from H. japonica, the investigation of saponins in H. japonica has not been reported until now. Methods: Various separation techniques, including polyporous resin column chromatography, silica gel column chromatography and hemi-preparative HPLC were applied to the isolation of triterpenoid saponins, and chemical methods such as acid hydrolysis and spectroscopic methods including HRESIMS and NMR were applied to their structure elucidation, and the XTT reduction method was used to assay cytotoxicity. Results: Two new triterpenoid saponins, named hylomeconoside A (1) and B (2) which were identified as 3-O-β-d-galactopyranosyl-(1→2)-β-d-glucuronopyranosyl-gypsogenin-28-O-β-d-xylopyranosyl-(1→3)-β-d-xylopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→2)-β-d-quinovopyranoside (1) and 3-O-β-d-galactopyranosyl-(1→2)-β-d-glucuronopyranosyl-gypsogenin-28-O-β-d-xylopyranosyl-(1→3)-β-d-xylopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→2)-α-l-arabinopyranoside (2), and two known triterpenoid saponins identified as dubioside C (3) and lucyoside P (4) on the basis of spectroscopic and chemical evidence, were isolated from H. japonica. Compound 1 exhibited moderate cytotoxicity on MGC-803 and HL-60 cells, with IC50 values of 43.8 and 32.4 μg·mL−1, respectively. Conclusions: Compounds 1 and 2 are new saponins, and 1 is considered to be one of the antitumor principles in this plant. This is the first time that triterpenoid saponins have been isolated from plants of the Papaveraceae family. View Full-Text
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Qu, Y.-F.; Gao, J.-Y.; Wang, J.; Geng, Y.-M.; Zhou, Y.; Sun, C.-X.; Li, F.; Feng, L.; Yu, M.-J.; Wang, G.-S. New Triterpenoid Saponins from the Herb Hylomecon japonica. Molecules 2017, 22, 1731.
Qu Y-F, Gao J-Y, Wang J, Geng Y-M, Zhou Y, Sun C-X, Li F, Feng L, Yu M-J, Wang G-S. New Triterpenoid Saponins from the Herb Hylomecon japonica. Molecules. 2017; 22(10):1731.Chicago/Turabian Style
Qu, Yan-Fei; Gao, Jing-Yu; Wang, Jing; Geng, Yan-Mei; Zhou, Yu; Sun, Cheng-Xin; Li, Fei; Feng, Lei; Yu, Meng-Juan; Wang, Guang-Shu. 2017. "New Triterpenoid Saponins from the Herb Hylomecon japonica." Molecules 22, no. 10: 1731.
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