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Special Issue "Metal Complexes of Biological Ligands"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organometallic Chemistry".

Deadline for manuscript submissions: 31 July 2018

Special Issue Editor

Guest Editor
Prof. Dr. Wolfgang Beck

Department Chemie, Ludwig-Maximilians-Universität, München, Germany
Website | E-Mail
Interests: metal complexes with biologically important ligands; metal complexes with pseudohalide ligands; organometallic chemistry; organometallic Lewis acids: hydrocarbon bridged metal complexes; metal complexes of dyes; nitrosyl metal complexes

Special Issue Information

Dear Colleagues,

The coordination chemistry of biometals, e.g., Cr, Mn, Fe, Co, Ni, Cu, Zn, and Mo, with biological ligands, comprises an important part in the field of the rapidly-growing Bioinorganic Chemistry. Metal complexes with bioligands play a decisive role for the understanding of biochemical processes. New results on metal complexes with essential biological ligands, amino acids, peptides, proteins, sugars, polysaccharides, nucleobases, nucleosides, DNA, RNA and natural macrocycles (e.g., porphyrins, haemes) find great interest, from structural, biochemical and even medicinal aspects. Other relevant bioligands are naturally-occurring heterocycles, sulfur ligands, phosphates, natural products, e.g., alkaloids, flavine, and vitamins. Metal complexes with nitrogen, carbon monoxide, nitrogen monoxide, oxygen, and carbon dioxide may exhibit biological aspects. For this Special Issue, bio-inspired model complexes are also highly welcome.

Researchers in this field are kindly invited to submit their results to this Special Issue. We are looking forward to receiving many fascinating reports.

Prof. Dr. Wolfgang Beck
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • metal complexes
  • bioligands
  • ligands in nature
  • biometals
  • coordination chemistry
  • organometallic chemistry

Published Papers (1 paper)

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Open AccessArticle Ni(II) Complexes with Schiff Base Ligands: Preparation, Characterization, DNA/Protein Interaction and Cytotoxicity Studies
Molecules 2017, 22(10), 1772; doi:10.3390/molecules22101772
Received: 14 September 2017 / Accepted: 16 October 2017 / Published: 24 October 2017
PDF Full-text (5276 KB) | HTML Full-text | XML Full-text | Supplementary Files
In this study, two Ni(II) complexes, namely [Ni(HL1)2(OAc)2] (1) and [Ni(L2)2] (2) (where HL1 and HL2 are (E)-1-((1-(2-hydroxyethyl)-1H-pyrazol-5-ylimino)methyl)-naphthalen-2-ol) and (E)-ethyl-5-((2-hydroxynaphthalen-1-yl)methyleneamino)-1-methyl-1H-pyrazole-4-carboxylate, respectively), were synthesized and characterized
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In this study, two Ni(II) complexes, namely [Ni(HL1)2(OAc)2] (1) and [Ni(L2)2] (2) (where HL1 and HL2 are (E)-1-((1-(2-hydroxyethyl)-1H-pyrazol-5-ylimino)methyl)-naphthalen-2-ol) and (E)-ethyl-5-((2-hydroxynaphthalen-1-yl)methyleneamino)-1-methyl-1H-pyrazole-4-carboxylate, respectively), were synthesized and characterized by X-ray crystallography, Electrospray Ionization Mass Spectrometry (ESI-MS), elemental analysis, and IR. Their uptake in biological macromolecules and cancer cells were preliminarily investigated through electronic absorption (UV-Vis), circular dichroism (CD) and fluorescence quenching measurements. Bovine serum albumin (BSA) interaction experiments were investigated by spectroscopy which showed that the complexes and ligands could quench the intrinsic fluorescence of BSA through an obvious static quenching process. The spectroscopic studies indicated that these complexes could bind to DNA via groove, non-covalent, and electrostatic interactions. Furthermore, in vitro methyl thiazolyl tetrazolium (MTT) assays and Annexin V/PI flow cytometry experiments were performed to assess the antitumor capacity of the complexes against eight cell lines. The results show that both of the complexes possess reasonable cytotoxicities. Full article
(This article belongs to the Special Issue Metal Complexes of Biological Ligands)

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