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Molecules 2017, 22(10), 1796; doi:10.3390/molecules22101796

Cyclodipeptides: An Overview of Their Biosynthesis and Biological Activity

1
Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Korea
2
Department of Biotechnology, Daegu Catholic University, Gyeongsan 38430, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 27 September 2017 / Revised: 18 October 2017 / Accepted: 19 October 2017 / Published: 23 October 2017
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Abstract

Cyclodipeptides (CDP) represent a diverse family of small, highly stable, cyclic peptides that are produced as secondary functional metabolites or side products of protein metabolism by bacteria, fungi, and animals. They are widespread in nature, and exhibit a broad variety of biological and pharmacological activities. CDP synthases (CDPSs) and non-ribosomal peptide synthetases (NRPSs) catalyze the biosynthesis of the CDP core structure, which is further modified by tailoring enzymes often associated with CDP biosynthetic gene clusters. In this review, we provide a comprehensive summary of CDP biosynthetic pathways and modifying enzymes. We also discuss the biological properties of some known CDPs and their possible applications in metabolic engineering. View Full-Text
Keywords: aa-tRNAsynthetase; cyclodipeptides; cyclodipeptide synthase; non-ribosomal peptide synthetase; tailoring enzyme aa-tRNAsynthetase; cyclodipeptides; cyclodipeptide synthase; non-ribosomal peptide synthetase; tailoring enzyme
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mishra, A.K.; Choi, J.; Choi, S.-J.; Baek, K.-H. Cyclodipeptides: An Overview of Their Biosynthesis and Biological Activity. Molecules 2017, 22, 1796.

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