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Molecules 2017, 22(10), 1792; doi:10.3390/molecules22101792

Phenolic Compounds Present Schinus terebinthifolius Raddi Influence the Lowering of Blood Pressure in Rats

1
Laboratório de Tecnologia de Alimentos, CCTA, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes 28013-602, Brazil
2
Laboratório de Clínica e Cirurgia Animal, CCTA, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes 28013-602, Brazil
3
Laboratório de Ciências Químicas, CCT, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes 28013-602, Brazil
4
Laboratório de Química de Bioativos Naturais, Departamento de Ciências Farmacêuticas, Universidade Federal Rural do Rio de Janeiro, Seropédica 23897-000, Brazil
5
Laboratório de Fitotecnia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes 28013-602, Brazil
*
Author to whom correspondence should be addressed.
Received: 28 September 2017 / Revised: 16 October 2017 / Accepted: 18 October 2017 / Published: 23 October 2017
(This article belongs to the Collection Bioactive Compounds)
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Abstract

This study identified two phenolic compounds in Schinus terebinthifolius Raddi fruits: naringenin (first report in this species) and gallic acid. Their structures were elucidated by nuclear magnetic resonance (NMR) data (1H-, 13C-NMR) and a high-performance liquid chromatography (HPLC) technique. A high content of phenolics (659.21 mg of gallic acid equivalents/g of sample—Folin-Ciocalteau method) and total flavonoids (140.69 mg of rutin equivalents/g of sample—aluminum chloride method) were quantified in S. terebinthifolius, as well as high antioxidant activity (77.47%—2,2-diphenyl-1-picrylhydrazyl, DPPH method). The antihypertensive activity related to its phenolic content was investigated. After intravenous infusion in Wistar rats, these phenolics significantly reduced (p < 0.05) the systolic, median, and diastolic arterial pressures of individuals. The rotarod test was performed to determine the mechanism of action of the sample vasorelaxant effect. It was found that its action exceeded that of the positive control used (diazepam). This confirmed the vasodilatory activity exerted by S. terebinthifolius fruits is related to the phenolic compounds present in the plant, which are potent antioxidants and inhibit oxidative stress, mainly in the central nervous system. View Full-Text
Keywords: Schinus terebinthifolius Raddi; Anacardiaceae; naringenin; gallic acid; blood pressure; rotarod Schinus terebinthifolius Raddi; Anacardiaceae; naringenin; gallic acid; blood pressure; rotarod
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de Lima Glória, L.; Barreto de Souza Arantes, M.; Menezes de Faria Pereira, S.; de Souza Vieira, G.; Xavier Martins, C.; Ribeiro de Carvalho Junior, A.; Antunes, F.; Braz-Filho, R.; José Curcino Vieira, I.; Leandro da Cruz, L.; Siqueira de Almeida Chaves, D.; de Paiva Freitas, S.; Barros de Oliveira, D. Phenolic Compounds Present Schinus terebinthifolius Raddi Influence the Lowering of Blood Pressure in Rats. Molecules 2017, 22, 1792.

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