Synthesis and Antitumor Activity of Triazole-Containing Sorafenib Analogs
AbstractUsing a highly effective binuclear Cu complex as the catalyst, the 1,3-dipolar cycloaddition reactions between 16 alkynes and two azides were successfully performed and resulted in the production of 25 new triazole-containing sorafenib analogs. Several compounds were evaluated as potent antitumor agents. Among them, 4-(4-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)phenoxy)-N-methylpicolinamide (8f) potently suppressed the proliferation of HT-29 cancer cells by inducing apoptosis and almost completely inhibited colony formation at a low micromolar concentration. View Full-Text
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Ye, W.; Yao, Q.; Yu, S.; Gong, P.; Qin, M. Synthesis and Antitumor Activity of Triazole-Containing Sorafenib Analogs. Molecules 2017, 22, 1759.
Ye W, Yao Q, Yu S, Gong P, Qin M. Synthesis and Antitumor Activity of Triazole-Containing Sorafenib Analogs. Molecules. 2017; 22(10):1759.Chicago/Turabian Style
Ye, Wenjing; Yao, Qi; Yu, Simiao; Gong, Ping; Qin, Mingze. 2017. "Synthesis and Antitumor Activity of Triazole-Containing Sorafenib Analogs." Molecules 22, no. 10: 1759.
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