Special Issue "Role of Lipids in Virus Replication"
QuicklinksA special issue of Viruses (ISSN 1999-4915).
Deadline for manuscript submissions: closed (28 February 2010)
Special Issue Editor
Guest Editor
Dr. Akira Ono
Department of Microbiology and Immunology, University of Michigan Medical School, 5736 Medical Science Building II, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0620, USA
Website: http://sitemaker.umich.edu/ono.lab/home
E-Mail:
Interests: roles played by membrane microdomain structures (lipid rafts) and phosphoinositides in virus replication; molecular mechanisms that determine the sites of virus assembly
Published Papers
Special Issue Information
Submission
All manuscripts should be submitted to viruses@mdpi.org with a copy to the Guest Editor. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed Open Access monthly journal published by MDPI.
Planned Papers
Title: Alphavirus Entry
Author: Margaret Kielian
Affiliation: Albert Einstein College of Medicine; E-Mail: margaret.kielian@einstein.yu.edu
Abstract: The study of enveloped animal viruses has greatly advanced our understanding of the general properties of membrane fusion and of the specific pathways that viruses use to infect the host cell. The class II membrane fusion proteins of the alphaviruses and flaviviruses have many similarities in structure and function. As reviewed here, alphaviruses use receptor-mediated endocytic uptake and low pH-triggered membrane fusion to deliver their RNA genomes into the cytoplasm. Recent advances in understanding the biochemistry and structure of the alphavirus membrane fusion protein provide a clearer picture of this fusion reaction, including the protein's conformational changes during fusion and the identification of key domains. These insights into the class II fusion mechanism suggest new areas for experimental investigation and potential inhibitor strategies for anti-viral therapy.
Title: Lipid Metabolism and HCV Infection
Author: John McLauchlan
Affiliation: MRC Institute of Virology; E-Mail: j.mclauchlan@mrcvu.gla.ac.uk
Type of Paper: Review
Title: Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function
Authors: Kenneth A. Stapleford 1 and David J. Miller 2
Affiliations: 1 Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA
2 Departments of Internal Medicine and Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; E-Mail: milldavi@med.umich.edu
Positive-sense RNA viruses are responsible for frequent and often devastating diseases in humans, animals, and plants. However, the development of effective vaccines and anti-viral therapies targeted towards these pathogens has been hindered by an incomplete understanding of the molecular mechanisms involved in viral replication. One common feature of all positive-sense RNA viruses is the manipulation of host intracellular membranes for the assembly of functional viral RNA replication complexes. This review will discuss the interplay between cellular membranes and positive-sense RNA virus replication, and will focus specifically on the potential structural and functional roles for cellular lipids in this process.
Title: Poxvirus Entry and Lipids
Author: Bernard Moss
Affiliation: National Institute of Allergy and Infectious Diseases, NIH; E-Mail: BMOSS@niaid.nih.gov
Title: Non-Enveloped Virus Assembly and Lipid Rafts
Authors: Bishnupriya Bhattacharya and Polly Roy
Affiliation: London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK; E-Mail: Polly.Roy@lshtm.ac.uk
Abstract: The non-enveloped viruses such as members of Picornaviridae and Reoviridae are assembled in the cytoplasm and are generally released by cell lysis. However, recent evidence suggests that some non-enveloped viruses exit infected cells without lysis indicating that these viruses may also utilise alternate means to exit. Moreover, it appears that some complex, non-enveloped viruses such as bluetongue virus (BTV) and rotavirus interact with lipid rafts and this interaction may play an important role in the non-lytic release of these viruses. This review will discuss the role of lipid rafts in the assembly and release of non-enveloped viruses, focusing mainly on BTV.
Title: Viral Lipidomics
Author: Kai Simons
Affiliation: Max-Planck-Institute of Molecular Cell Biology and Genetics; E-Mail: otto@mpi-cbg.de (secretary)
Title: Retrovirus Replication and Lipids
Authors: Abdul Waheed and Eric Freed
Affiliation: National Cancer Institute, NIH; E-Mail: waheedab@mail.nih.gov
Title: Non-Enveloped Virus Entry and Glycolipids
Author: Christiane Wobus
Affiliation: University of Michigan Medical School; E-Mail: cwobus@umich.edu
Title: Lipid Domains and Virus Budding/Membrane Curvature
Author: Joshua Zimmerberg
Affiliation: National Institute of Child Health and Development, NIH; E-Mail: zimmerbj@mail.nih.gov
Last update: 12 February 2010