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Viruses 2010, 2(4), 1011-1049; doi:10.3390/v2041011
Review

Glycosphingolipids as Receptors for Non-Enveloped Viruses

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Received: 2 March 2010 / Revised: 9 April 2010 / Accepted: 13 April 2010 / Published: 15 April 2010
(This article belongs to the Special Issue Role of Lipids in Virus Replication)
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Abstract

Glycosphingolipids are ubiquitous molecules composed of a lipid and a carbohydrate moiety. Their main functions are as antigen/toxin receptors, in cell adhesion/recognition processes, or initiation/modulation of signal transduction pathways. Microbes take advantage of the different carbohydrate structures displayed on a specific cell surface for attachment during infection. For some viruses, such as the polyomaviruses, binding to gangliosides determines the internalization pathway into cells. For others, the interaction between microbe and carbohydrate can be a critical determinant for host susceptibility. In this review, we summarize the role of glycosphingolipids as receptors for members of the non-enveloped calici-, rota-, polyoma- and parvovirus families.
Keywords: non-enveloped virus; glycosphingolipid; receptor; calicivirus; rotavirus; polyomavirus; parvovirus non-enveloped virus; glycosphingolipid; receptor; calicivirus; rotavirus; polyomavirus; parvovirus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Taube, S.; Jiang, M.; Wobus, C.E. Glycosphingolipids as Receptors for Non-Enveloped Viruses. Viruses 2010, 2, 1011-1049.

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