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The Role of Lipids in Retrovirus Replication
Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA
* Author to whom correspondence should be addressed.
Received: 22 March 2010; in revised form: 23 April 2010 / Accepted: 27 April 2010 / Published: 6 May 2010
Abstract: Retroviruses undergo several critical steps to complete a replication cycle. These include the complex processes of virus entry, assembly, and budding that often take place at the plasma membrane of the host cell. Both virus entry and release involve membrane fusion/fission reactions between the viral envelopes and host cell membranes. Accumulating evidence indicates important roles for lipids and lipid microdomains in virus entry and egress. In this review, we outline the current understanding of the role of lipids and membrane microdomains in retroviral replication.
Keywords: retroviruses; phospholipids; sphingolipids; cholesterol; PI(4,5)P2; lipid rafts; entry; assembly; budding
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Cite This Article
MDPI and ACS Style
Waheed, A.A.; Freed, E.O. The Role of Lipids in Retrovirus Replication. Viruses 2010, 2, 1146-1180.
Waheed AA, Freed EO. The Role of Lipids in Retrovirus Replication. Viruses. 2010; 2(5):1146-1180.
Waheed, Abdul A.; Freed, Eric O. 2010. "The Role of Lipids in Retrovirus Replication." Viruses 2, no. 5: 1146-1180.