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Viruses 2010, 2(5), 1146-1180; doi:10.3390/v2051146

The Role of Lipids in Retrovirus Replication

Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA
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Received: 22 March 2010 / Revised: 23 April 2010 / Accepted: 27 April 2010 / Published: 6 May 2010
(This article belongs to the Special Issue Role of Lipids in Virus Replication)
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Abstract

Retroviruses undergo several critical steps to complete a replication cycle. These include the complex processes of virus entry, assembly, and budding that often take place at the plasma membrane of the host cell. Both virus entry and release involve membrane fusion/fission reactions between the viral envelopes and host cell membranes. Accumulating evidence indicates important roles for lipids and lipid microdomains in virus entry and egress. In this review, we outline the current understanding of the role of lipids and membrane microdomains in retroviral replication. View Full-Text
Keywords: retroviruses; phospholipids; sphingolipids; cholesterol; PI(4,5)P2; lipid rafts; entry; assembly; budding retroviruses; phospholipids; sphingolipids; cholesterol; PI(4,5)P2; lipid rafts; entry; assembly; budding
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Waheed, A.A.; Freed, E.O. The Role of Lipids in Retrovirus Replication. Viruses 2010, 2, 1146-1180.

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