Next Article in Journal
Special Issue: Retroviral Enzymes
Next Article in Special Issue
Lipid Metabolism and HCV Infection
Previous Article in Journal
Interactions of Host Proteins with the Murine Leukemia Virus Integrase
Previous Article in Special Issue
Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function
Viruses 2010, 2(5), 1146-1180; doi:10.3390/v2051146

The Role of Lipids in Retrovirus Replication

*  and
Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA
* Author to whom correspondence should be addressed.
Received: 22 March 2010 / Revised: 23 April 2010 / Accepted: 27 April 2010 / Published: 6 May 2010
(This article belongs to the Special Issue Role of Lipids in Virus Replication)
View Full-Text   |   Download PDF [933 KB, uploaded 12 May 2015]   |   Browse Figures


Retroviruses undergo several critical steps to complete a replication cycle. These include the complex processes of virus entry, assembly, and budding that often take place at the plasma membrane of the host cell. Both virus entry and release involve membrane fusion/fission reactions between the viral envelopes and host cell membranes. Accumulating evidence indicates important roles for lipids and lipid microdomains in virus entry and egress. In this review, we outline the current understanding of the role of lipids and membrane microdomains in retroviral replication.
Keywords: retroviruses; phospholipids; sphingolipids; cholesterol; PI(4,5)P2; lipid rafts; entry; assembly; budding retroviruses; phospholipids; sphingolipids; cholesterol; PI(4,5)P2; lipid rafts; entry; assembly; budding
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Waheed, A.A.; Freed, E.O. The Role of Lipids in Retrovirus Replication. Viruses 2010, 2, 1146-1180.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert