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Viruses 2010, 2(5), 1055-1068; doi:10.3390/v2051055

Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function

Received: 31 January 2010 / Revised: 7 April 2010 / Accepted: 22 April 2010 / Published: 29 April 2010
(This article belongs to the Special Issue Role of Lipids in Virus Replication)
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Positive-sense RNA viruses are responsible for frequent and often devastating diseases in humans, animals, and plants. However, the development of effective vaccines and anti-viral therapies targeted towards these pathogens has been hindered by an incomplete understanding of the molecular mechanisms involved in viral replication. One common feature of all positive-sense RNA viruses is the manipulation of host intracellular membranes for the assembly of functional viral RNA replication complexes. This review will discuss the interplay between cellular membranes and positive-sense RNA virus replication, and will focus specifically on the potential structural and functional roles for cellular lipids in this process.
Keywords: RNA viruses; replication; membranes; lipids RNA viruses; replication; membranes; lipids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Stapleford, K.A.; Miller, D.J. Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function. Viruses 2010, 2, 1055-1068.

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