Next Article in Journal
HIV-1 Entry, Inhibitors, and Resistance
Next Article in Special Issue
The Role of Lipids in Retrovirus Replication
Previous Article in Journal
Surf and Turf: Mechanism of Enhanced Virus Spread During Poxvirus Infection
Previous Article in Special Issue
Glycosphingolipids as Receptors for Non-Enveloped Viruses
Viruses 2010, 2(5), 1055-1068; doi:10.3390/v2051055
Review

Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function

1
 and
2,3,*
1 Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA 2 Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA 3 Department of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
* Author to whom correspondence should be addressed.
Received: 31 January 2010 / Revised: 7 April 2010 / Accepted: 22 April 2010 / Published: 29 April 2010
(This article belongs to the Special Issue Role of Lipids in Virus Replication)
View Full-Text   |   Download PDF [1025 KB, uploaded 12 May 2015]   |  

Abstract

Positive-sense RNA viruses are responsible for frequent and often devastating diseases in humans, animals, and plants. However, the development of effective vaccines and anti-viral therapies targeted towards these pathogens has been hindered by an incomplete understanding of the molecular mechanisms involved in viral replication. One common feature of all positive-sense RNA viruses is the manipulation of host intracellular membranes for the assembly of functional viral RNA replication complexes. This review will discuss the interplay between cellular membranes and positive-sense RNA virus replication, and will focus specifically on the potential structural and functional roles for cellular lipids in this process.
Keywords: RNA viruses; replication; membranes; lipids RNA viruses; replication; membranes; lipids
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Stapleford, K.A.; Miller, D.J. Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function. Viruses 2010, 2, 1055-1068.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert