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Viruses 2010, 2(5), 1218-1235; doi:10.3390/v2051218

Role of Lipids on Entry and Exit of Bluetongue Virus, a Complex Non-Enveloped Virus

London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK
* Author to whom correspondence should be addressed.
Received: 17 March 2010 / Revised: 4 May 2010 / Accepted: 11 May 2010 / Published: 18 May 2010
(This article belongs to the Special Issue Role of Lipids in Virus Replication)
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Non-enveloped viruses such as members of Picornaviridae and Reoviridae are assembled in the cytoplasm and are generally released by cell lysis. However, recent evidence suggests that some non-enveloped viruses exit from infected cells without lysis, indicating that these viruses may also utilize alternate means for egress. Moreover, it appears that complex, non-enveloped viruses such as bluetongue virus (BTV) and rotavirus interact with lipids during their entry process as well as with lipid rafts during the trafficking of newly synthesized progeny viruses. This review will discuss the role of lipids in the entry, maturation and release of non-enveloped viruses, focusing mainly on BTV.
Keywords: BTV; non enveloped; lipid rafts; entry; exit BTV; non enveloped; lipid rafts; entry; exit
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bhattacharya, B.; Roy, P. Role of Lipids on Entry and Exit of Bluetongue Virus, a Complex Non-Enveloped Virus. Viruses 2010, 2, 1218-1235.

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