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Role of Lipids on Entry and Exit of Bluetongue Virus, a Complex Non-Enveloped Virus
London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK
* Author to whom correspondence should be addressed.
Received: 17 March 2010; in revised form: 4 May 2010 / Accepted: 11 May 2010 / Published: 18 May 2010
Abstract: Non-enveloped viruses such as members of Picornaviridae and Reoviridae are assembled in the cytoplasm and are generally released by cell lysis. However, recent evidence suggests that some non-enveloped viruses exit from infected cells without lysis, indicating that these viruses may also utilize alternate means for egress. Moreover, it appears that complex, non-enveloped viruses such as bluetongue virus (BTV) and rotavirus interact with lipids during their entry process as well as with lipid rafts during the trafficking of newly synthesized progeny viruses. This review will discuss the role of lipids in the entry, maturation and release of non-enveloped viruses, focusing mainly on BTV.
Keywords: BTV; non enveloped; lipid rafts; entry; exit
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Bhattacharya, B.; Roy, P. Role of Lipids on Entry and Exit of Bluetongue Virus, a Complex Non-Enveloped Virus. Viruses 2010, 2, 1218-1235.
Bhattacharya B, Roy P. Role of Lipids on Entry and Exit of Bluetongue Virus, a Complex Non-Enveloped Virus. Viruses. 2010; 2(5):1218-1235.
Bhattacharya, Bishnupriya; Roy, Polly. 2010. "Role of Lipids on Entry and Exit of Bluetongue Virus, a Complex Non-Enveloped Virus." Viruses 2, no. 5: 1218-1235.