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Lipid Metabolism and HCV Infection
Pfizer Global Research & Development, Infectious Diseases Group, Sandwich Laboratories, Sandwich, CT13 9NJ, UK
Immune Disease Institute, Harvard Medical School, Department of Microbiology and Molecular Genetics, Boston, MA 02115, USA
Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, PO Box 412, Westmead, NSW 2145, Australia
MRC Virology Unit, Church Street, Glasgow G11 5JR, UK
* Author to whom correspondence should be addressed.
Received: 22 March 2010; in revised form: 5 May 2010 / Accepted: 6 May 2010 / Published: 11 May 2010
Abstract: Chronic infection by hepatitis C virus (HCV) can lead to severe liver disease and is a global healthcare problem. The liver is highly metabolically active and one of its key functions is to control the balance of lipid throughout the body. A number of pathologies have been linked to the impact of HCV infection on liver metabolism. However, there is also growing evidence that hepatic metabolic processes contribute to the HCV life cycle. This review summarizes the relationship between lipid metabolism and key stages in the production of infectious HCV.
Keywords: hepatitis C virus; HCV; lipid metabolism; lipid droplets; fatty acid biosynthesis; cholesterol biosynthesis; VLDL assembly; RNA replication; virus assembly
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Cite This Article
MDPI and ACS Style
Targett-Adams, P.; Boulant, S.; Douglas, M.W.; McLauchlan, J. Lipid Metabolism and HCV Infection. Viruses 2010, 2, 1195-1217.
Targett-Adams P, Boulant S, Douglas MW, McLauchlan J. Lipid Metabolism and HCV Infection. Viruses. 2010; 2(5):1195-1217.
Targett-Adams, Paul; Boulant, Steeve; Douglas, Mark W.; McLauchlan, John. 2010. "Lipid Metabolism and HCV Infection." Viruses 2, no. 5: 1195-1217.