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Viruses 2010, 2(5), 1195-1217; doi:10.3390/v2051195

Lipid Metabolism and HCV Infection

1
Pfizer Global Research & Development, Infectious Diseases Group, Sandwich Laboratories, Sandwich, CT13 9NJ, UK
2
Immune Disease Institute, Harvard Medical School, Department of Microbiology and Molecular Genetics, Boston, MA 02115, USA
3
Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, PO Box 412, Westmead, NSW 2145, Australia
4
MRC Virology Unit, Church Street, Glasgow G11 5JR, UK
*
Author to whom correspondence should be addressed.
Received: 22 March 2010 / Revised: 5 May 2010 / Accepted: 6 May 2010 / Published: 11 May 2010
(This article belongs to the Special Issue Role of Lipids in Virus Replication)
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Abstract

Chronic infection by hepatitis C virus (HCV) can lead to severe liver disease and is a global healthcare problem. The liver is highly metabolically active and one of its key functions is to control the balance of lipid throughout the body. A number of pathologies have been linked to the impact of HCV infection on liver metabolism. However, there is also growing evidence that hepatic metabolic processes contribute to the HCV life cycle. This review summarizes the relationship between lipid metabolism and key stages in the production of infectious HCV. View Full-Text
Keywords: hepatitis C virus; HCV; lipid metabolism; lipid droplets; fatty acid biosynthesis; cholesterol biosynthesis; VLDL assembly; RNA replication; virus assembly hepatitis C virus; HCV; lipid metabolism; lipid droplets; fatty acid biosynthesis; cholesterol biosynthesis; VLDL assembly; RNA replication; virus assembly
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Targett-Adams, P.; Boulant, S.; Douglas, M.W.; McLauchlan, J. Lipid Metabolism and HCV Infection. Viruses 2010, 2, 1195-1217.

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