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Special Issue "Novel Approaches to Biosensing with Nanoparticles"

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: 10 December 2017

Special Issue Editors

Guest Editor
Prof. Dr. Alessandra Maria Bossi

Dipartimento di Biotecnologie, Università di Verona, Strada Le Grazie 15, 37134 Verona, Italy
Website | E-Mail
Interests: protein imprinting; molecular recognition; polymer synthesis; responsive polymers; nanoparticles; analytical methods
Guest Editor
Dr. Michael James Whitcombe

Department of Chemistry, College of Science and Engineering, University of Leicester, Leicester, UK
Website | E-Mail
Interests: molecular imprinting; polymer synthesis; molecular recognition; organic synthesis; sensors

Special Issue Information

Dear Colleagues,

Under the working principle of biosensors, i.e. the integration of biological, or biomimetic, recognition elements to a transducer to a generate a digital readout signal that is proportional to the target analyte, which is easily understood by the operator, important advances in the analytical field have been reported; such as the development of the glucosimeter. The innovations of biosensor are under continuous development, and encompasses receptors, biomimetics, electronics, transduction, and the latest cell-phone readouts. Within the innovation panorama, the integration of nanomaterials and nanoparticles into biosensing is an area under wide expansion. Because nanomaterials offer unique surface-to-volume ratios, outstanding surface properties, and unique optical and electrical behaviors, their application in biosensing is intended as a means to boost biosensor performance and reach improved sensitivities and signal transduction. In order to highlight some of the latest nanoparticle-biosensor advances, we would like to invite you to consider submitting a manuscript to our upcoming Special Issue, “Novel Approaches to Biosensing with Nanoparticles”, to be published in the beginning of 2018. Under the expanded scope of the journal, the aim of this Special Issue is to gather a collection of papers dedicated to all aspects of nanoparticles in biosensing, with a particular emphasis on novel approaches to sensor design and architecture, signal transduction and novel applications.

We welcome submissions from any area of biosensing, provided that nanoparticles are involved in sensor design or use. Both research papers and review articles will be considered. If you are interested in contributing to this Special Issue, we would very much appreciate receiving the tentative title of your contribution.

Prof. Dr. Alessandra Maria Bossi
Dr. Michael James Whitcombe
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanoparticles
  • Nanobiosensors
  • Nanoplasmonics
  • Quantum dots
  • Metal nanoparticles
  • Fullerenes
  • Nanodiamond
  • Nanotubes
  • Electrochemical Sensors
  • Optical Sensors

Published Papers (4 papers)

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Research

Open AccessArticle A New Hydrogen Sensor Based on SNS Fiber Interferometer with Pd/WO3 Coating
Sensors 2017, 17(9), 2144; doi:10.3390/s17092144
Received: 27 July 2017 / Revised: 11 September 2017 / Accepted: 15 September 2017 / Published: 18 September 2017
PDF Full-text (2164 KB) | HTML Full-text | XML Full-text
Abstract
This paper presents a new hydrogen sensor based on a single mode–no core–single mode (SNS) fiber interferometer structure. The surface of the no core fiber (NCF) was coated by Pd/WO3 film to detect the variation of hydrogen concentration. If the hydrogen concentration
[...] Read more.
This paper presents a new hydrogen sensor based on a single mode–no core–single mode (SNS) fiber interferometer structure. The surface of the no core fiber (NCF) was coated by Pd/WO3 film to detect the variation of hydrogen concentration. If the hydrogen concentration changes, the refractive index of the Pd/WO3 film as well as the boundary condition for light propagating in the NCF will all be changed, which will then cause a shift into the resonant wavelength of interferometer. Therefore, the hydrogen concentration can be deduced by measuring the shift of the resonant wavelength. Experimental results demonstrated that this proposed sensor had a high detection sensitivity of 1.26857 nm/%, with good linearity and high accuracy (maximum 0.0055% hydrogen volume error). Besides, it also possessed the advantages of simple structure, low cost, good stability, and repeatability. Full article
(This article belongs to the Special Issue Novel Approaches to Biosensing with Nanoparticles)
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Open AccessArticle A Simple and Selective Fluorescent Sensor Chip for Indole-3-Butyric Acid in Mung Bean Sprouts Based on Molecularly Imprinted Polymer Coatings
Sensors 2017, 17(9), 1954; doi:10.3390/s17091954
Received: 26 July 2017 / Revised: 15 August 2017 / Accepted: 22 August 2017 / Published: 24 August 2017
PDF Full-text (3192 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
In this paper, we report the preparation of molecularly imprinted polymer coatings on quartz chips for selective solid-phase microextraction and fluorescence sensing of the auxin, indole-3-butyric acid. The multiple copolymerization method was used to prepare polymer coatings on silylated quartz chips. The polymer
[...] Read more.
In this paper, we report the preparation of molecularly imprinted polymer coatings on quartz chips for selective solid-phase microextraction and fluorescence sensing of the auxin, indole-3-butyric acid. The multiple copolymerization method was used to prepare polymer coatings on silylated quartz chips. The polymer preparation conditions (e.g., the solvent, monomer, and cross-linker) were investigated systemically to enhance the binding performance of the imprinted coatings. Direct solid-phase fluorescence measurements on the chips facilitated monitoring changes in coating performance. The average binding capacity of an imprinted polymer coated chip was approximately 152.9 µg, which was higher than that of a non-imprinted polymer coated chip (60.8 µg); the imprinted coatings showed the highest binding to IBA among the structural analogues, indicating that the coatings possess high selectivity toward the template molecule. The developed method was used for the determination of the auxin in mung bean extraction, and the recovery was found to be in the range of 91.5% to 97.5%, with an RSD (n = 3) of less than 7.4%. Thus, the present study provides a simple method for fabricating a fluorescent sensor chip for selective analysis. Full article
(This article belongs to the Special Issue Novel Approaches to Biosensing with Nanoparticles)
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Open AccessArticle Investigating the Influence of Temperature on the Kaolinite-Base Synthesis of Zeolite and Urease Immobilization for the Potential Fabrication of Electrochemical Urea Biosensors
Sensors 2017, 17(8), 1831; doi:10.3390/s17081831
Received: 29 May 2017 / Revised: 15 July 2017 / Accepted: 22 July 2017 / Published: 8 August 2017
PDF Full-text (19454 KB) | HTML Full-text | XML Full-text
Abstract
Temperature-dependent zeolite synthesis has revealed a unique surface morphology, surface area and pore size which influence the immobilization of urease on gold electrode supports for biosensor fabrication. XRD characterization has identified zeolite X (Na) at all crystallization temperatures tested. However, N2 adsorption
[...] Read more.
Temperature-dependent zeolite synthesis has revealed a unique surface morphology, surface area and pore size which influence the immobilization of urease on gold electrode supports for biosensor fabrication. XRD characterization has identified zeolite X (Na) at all crystallization temperatures tested. However, N2 adsorption and desorption results showed a pore size and pore volume of zeolite X (Na) 60 °C, zeolite X (Na) 70 °C and zeolite X (Na) 90 °C to range from 1.92 nm to 2.45 nm and 0.012 cm3/g to 0.061 cm3/g, respectively, with no significant differences. The specific surface area of zeolite X (Na) at 60, 70 and 90 °C was 64 m2/g, 67 m2/g and 113 m2/g, respectively. The pore size, specific surface area and pore volumes of zeolite X (Na) 80 °C and zeolite X (Na) 100 °C were dramatically increased to 4.21 nm, 295 m2/g, 0.762 cm3/g and 4.92 nm, 389 m2/g, 0.837 cm3/g, in that order. The analytical performance of adsorbed urease on zeolite X (Na) surface was also investigated using cyclic voltammetry measurements, and the results showed distinct cathodic and anodic peaks by zeolite X (Na) 80 °C and zeolite X (Na) 100 °C. These zeolites’ molar conductance was measured as a function of urea concentration and gave an average polynomial regression fit of 0.948. The findings in this study suggest that certain physicochemical properties, such as crystallization temperature and pH, are critical parameters for improving the morphological properties of zeolites synthesized from natural sources for various biomedical applications. Full article
(This article belongs to the Special Issue Novel Approaches to Biosensing with Nanoparticles)
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Open AccessArticle Adenosine Triphosphate-Encapsulated Liposomes with Plasmonic Nanoparticles for Surface Enhanced Raman Scattering-Based Immunoassays
Sensors 2017, 17(7), 1480; doi:10.3390/s17071480
Received: 22 May 2017 / Revised: 21 June 2017 / Accepted: 21 June 2017 / Published: 23 June 2017
PDF Full-text (2076 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
In this study, we prepared adenosine triphosphate (ATP) encapsulated liposomes, and assessed their applicability for the surface enhanced Raman scattering (SERS)-based assays with gold-silver alloy (Au@Ag)-assembled silica nanoparticles (NPs; SiO2@Au@Ag). The liposomes were prepared by the thin film hydration method from
[...] Read more.
In this study, we prepared adenosine triphosphate (ATP) encapsulated liposomes, and assessed their applicability for the surface enhanced Raman scattering (SERS)-based assays with gold-silver alloy (Au@Ag)-assembled silica nanoparticles (NPs; SiO2@Au@Ag). The liposomes were prepared by the thin film hydration method from a mixture of l-α-phosphatidylcholine, cholesterol, and PE-PEG2000 in chloroform; evaporating the solvent, followed by hydration of the resulting thin film with ATP in phosphate-buffered saline (PBS). Upon lysis of the liposome, the SERS intensity of the SiO2@Au@Ag NPs increased with the logarithm of number of ATP-encapsulated liposomes after lysis in the range of 8 × 106 to 8 × 1010. The detection limit of liposome was calculated to be 1.3 × 10−17 mol. The successful application of ATP-encapsulated liposomes to SiO2@Au@Ag NPs based SERS analysis has opened a new avenue for Raman label chemical (RCL)-encapsulated liposome-enhanced SERS-based immunoassays. Full article
(This article belongs to the Special Issue Novel Approaches to Biosensing with Nanoparticles)
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