Special Issue "ISFET Sensors"

Guest Editor
Prof. Dr. Nicole Jaffrezic-Renault
CNRS Laboratory of Analytical Sciences, Claude Bernard University Lyon 1, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France
Website: http://www.univ-lyon1.fr
E-Mail:
Interests: biosensors; impedance; immunosensors; conductometric sensors; enzymatic sensors; affinity sensors

This issue is devoted to the field effect structures for biosensing from the microscopic scale (EIS, ISFET) to the nanoscale (NanoFET) based on silicon nano/microtechnology or on organic nano/micro technology. Contributions on the integration of these field effect structures in lab-on-chips are of high interest for this special issue. All types of applications using field effect structures for on-line detection will be accepted.

Submission

Sensors (http://www.mdpi.org/sensors/) is a highly rated journal with a 1.870 impact factor in 2008. Sensors is indexed and abstracted very quickly by Chemical Abstracts, Analytical Abstracts, Science Citation Index Expanded, Chemistry Citation Index, Scopus and Google Scholar.

All papers should be submitted to sensors@mdpi.org with copy to the guest editor, E-mail: Nicole.Jaffrezic@univ-lyon1.fr. To be published continuously until the deadline and papers will be listed together at the special websites.

Please visit the instructions for authors at http://www.mdpi.org/sensors/publguid.htm before submitting a paper. Open Access publication fees are 1050 CHF per paper. English correction fees (250 CHF) will be added in certain cases (1300 CHF per paper for those papers that require extensive additional formatting and/or English corrections.).

• ISFET sensors
• biosensing
• microscopic scale (EIS, ISFET)
• nanoscale (NanoFET)
• silicon nano/microtechnology
• organic nano/micro technology

Title: ISFET Biosensors Based on Wide Band Gap Semiconducting Materials
Authors: Rositza Yakimova, Kajsa Uvdal, Anita Lloyd Spetz
Affiliation: Department of Physics, Chemistry and Biology, Linköping University, SE-581 83 Linköping, Sweden; E-Mail: roy@ifm.liu.se
Abstract: There is a need for new inventive transducer concepts in order to, for example, create biosensors robust enough for the environment in the body and biosensors for remote sensing. In recent developments the traditional Si based Ion Sensitive Field Effect (ISFET) biosensors have been replaced by such made on wide band gap semiconductors like GaN, SiC and ZnO. The latest progress in this area will be reviewed. An emphasis is given on ZnO due to the combination of the semiconductor and oxide properties. Surface bio-functionalization of ZnO and GaN is demonstrated by APTES, MPA or MP-TMS molecules. XPS and electrochemical impedance spectroscopy are used to characterize the organic/inorganic interfaces. In order to improve the transducer in the ISFET biosensor, a development of an ISFET device with built in reference electrode for liquid sensing is described. Processing of more complicated sensors, such as nanowire FETs will also be reviewed.

Title: Non-Faradic FET-based Sensors for Integrated Solution
Authors: Edwin C. Kan and Nini L. Munoz
Affiliation: Cornell University, 404 Phillips Hall, Ithaca, NY 14853, USA; E-Mails: kan@ece.cornell.edu; nlm9@cornell.edu

Title: Immuno-Enzymatic Biosensor Based on the ISFETs for the Registration of some Micotoxins
Author: N.F. Starodub
Affiliation: National University of Life and Environmental Sciences, 15 Herojev Oboroni Str., Kiev, 03041 Ukraine
Abstract: Mycotoxins are big group which includes more than 300 individual agents produced by different fungi strains. T2, aflatoxins, searelenone, patulin and others cause a grate interest since they are widespread and characterized by the high level of toxicity. They may be prepared by the very simple way. Both circumstances (simplicity obtaining and high level of toxicity) form very serious problem since these toxins may be as instrument for bioterrorists. Unfortunately the analytical methodologies for their analysis are extremely high complicate, routine, expensive and time consumable. Early we developed some optical immune biosensors to overcome these disadvantages. Unfortunately their sensitivity in a number of cases should be improved. To achieve the sensitivity needed for practice now we worked out immune-enzymatic biosensors based on the ISFETs. Their efficiency at the determination of patulin and T2 mycotoxin is demonstrated in this article.

Title: IsFETs Based on the Oxide Cerium: Their Physical and Functional Characteristics at the Determination of some Biochemical Quantities
Authors: A.N. Shmyryeva ¹ and N.F. Starodub ²
Affiliations: ¹ Kiev National Technical University of Ukraine, 37 Prospect Peremohy, Kyiv, 03056, Ukraine
² National University of Life and Environmental Sciences, 15 Herojev Oboroni Str., Kiev, 03041 Ukraine
Abstract: IsFET’s with the dielectric based on the oxide cerium layers intended for the creation of very sensitive, stable and reliable biosensors were studied. Input and output characteristics of the IsFET’s with the Si3N4 and CeOх dielectrics shown the increasing of the pH-sensitivity in the respect of the drain current in case of the CeOх. It is due to high density of the surface sensitive centers (up to 1020 м-2), large level of the permittivity (ε = 26) and the band-gap energy (3.6 eV) of cerium. All these effects lead to decreasing of the current losses through the dielectric. According to the site-binding theory it was investigated the physical-chemical processes taking palaces at the surface layer of the CeOх at its interaction with the some biochemical complexes. IsFETs had the increased pH-sensitivity (about 58 mV/pH) that was near to the maximal possible index (59 mV/pH) for the structures of the semiconductor-insulator-solution. Taking into account the high chemical stability of the CeOх as well as the simplicity of obtaining of the thin layers of this dielectric it may be recommended for the creation of the multi-biosensors for medical diagnostics and environmental monitoring. We tested the efficiency of this structure at the control of some toxic substances in the model solution.