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• Kim, SKyu
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Sensors 2009, 9(9), 7111-7131; doi:10.3390/s90907111

Review

Ion-Sensitive Field-Effect Transistor for Biological Sensing

Chang-Soo Lee ¹ , Sang Kyu Kim ^1,2  and Moonil Kim ^1,*

¹ BioNanotechnology Research Center (BNRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-333, Korea ² School of Engineering, University of Science and Technology (UST), Daejeon 305-333, Korea

* Author to whom correspondence should be addressed.

Received: 4 August 2009; in revised form: 27 August 2009 / Accepted: 31 August 2009 / Published: 7 September 2009

(This article belongs to the Special Issue ISFET Sensors)

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Abstract: In recent years there has been great progress in applying FET-type biosensors for highly sensitive biological detection. Among them, the ISFET (ion-sensitive field-effect transistor) is one of the most intriguing approaches in electrical biosensing technology. Here, we review some of the main advances in this field over the past few years, explore its application prospects, and discuss the main issues, approaches, and challenges, with the aim of stimulating a broader interest in developing ISFET-based biosensors and extending their applications for reliable and sensitive analysis of various biomolecules such as DNA, proteins, enzymes, and cells.

Keywords: ISFET; ion-sensitive field-effect transistor; biosensor; biomolecules

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