Special Issue "Polymers for Drug Delivery"
A special issue of Polymers (ISSN 2073-4360).
Deadline for manuscript submissions: closed (30 November 2013)
Prof. Dr. Gianfranco Pasut
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, Padova 35131, Italy
Phone: +39 049 827 5694
Fax: +39 049 827 5366
Interests: polymer-drug and polymer-protein conjugates; PEGylation; enzymatic conjugation; site-selective polymer conjugation; enzymatic conjugation; tumor targeted anticancer conjugates; conjugates for combination therapy; hyaluronic acid as drug carrier; stealth liposomes
Polymers have performed and will continue to play a central role in drug delivery. These macromolecules are now being used in several drug delivery approaches (e.g., drug and protein conjugates, micro and nanoparticles, nanocapsules, matrices and hydrogels, polymersomes, complexing polymers etc.) or are themselves drugs (e.g., polymers for molecular sequestration). Polymers have, moreover, also been exploited to improve the performance of other drug delivery systems (e.g., stealth liposomes). In view of this vast scenario of applications, researchers continue to propose new polymers characterized by improved features and biocompatibility as well as innovative applications. Some have also been designed to successfully replace the current gold standard for stealth coatings, polyethylene glycol (PEG). The sum of these research activities has yielded a growing number of polymer-based products that have been approved by regulatory authorities or are under investigation in clinical trials.
Relevant, “smart” carriers are needed to recapture the interest of the pharmaceutical industry which has the means to cover research costs to develop new polymers for human use. Collaboration between academia and the pharmaceutical industry must be promoted if research findings in the laboratory are to be taken to the bedside. As researchers design new studies in this field, it is important that they address vital issues such as reproducible synthesis, biodegradability of polymers, elimination pathways, biocompatibility, storage stability, polydispersity, polymer characterization methods, feasibility of selective chemical modification, etc.
This issue aims to review the current state-of-the-art concerning polymeric drug delivery systems and to envision future perspectives. The topical subjects to be addressed include: synthetic polymers, natural polymers, bioconjugation of polymers, smart polymers, amphiphilic polymers, bioactive polymers, the dynamics of polymers crossing biological barriers, targeted drug delivery, polymers as drugs, etc.
Prof. Dr. Gianfranco Pasut
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed Open Access quarterly journal published by MDPI.
- drug delivery
- bio-responsive polymers
- biocompatible polymers
- amphiphilic polymers
- smart polymers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Article
Title: “Micromolded Polymer Hollow Microneedles for Rapid Intradermal Delivery of Liquid Formulations”
Author: Marion Sausse Lhernould
Affiliation: Université Libre de Bruxelles, BEAMS dpt, Av F.D. Roosevelt 50, B-1050 Bruxelles, Belgium; Tel.: +32(0)2 650 47 66; E-mail: firstname.lastname@example.org
Abstract: “This paper will present our latest prototype of hollow polymer microneedle array. It has been manufactured in polymer using an innovative micro-molding and excimer laser technologies stacking. This prototype allows rapid intradermal delivery of liquid formulations. It is associated to an applicator device using an impaction mechanism, which insures the correct penetration of all needles. The article will present its characteristics in terms of mechanical strength, insertion force, penetration properties and pharmacokinetics.”
Type of Paper: Review
Title: Polyester Dendrimers: Smart Carriers for Drug Delivery Applications
Author: Jean-d'Amour Twibanire
Affiliation: Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada; Email: twibanire@Dal.Ca
Abstract: There are now many families of dendrimers, each with interesting properties, since the surface, interior and core can be tailored to different sorts of applications. Many potential applications of dendrimers are based on their unparalleled molecular uniformity, multifunctional surface and presence of internal cavities. These specific properties make dendrimers suitable for a variety of high technology uses including biomedical and industrial applications. Properties like polyvalency, defined architecture, size and shape control, loading capacity, and biocompatibility could be exploited singularly or in combination, making it possible to use dendrimers in a large variety of fields. Biodegradable dendrimers are commonly prepared by inclusion of ester groups in the polymer backbone, which are chemically labile and/or enzymatically cleaved in physiological conditions. This review surveys advances on polyester dendrimers as smart carriers for drug delivery applications.
Type of Paper: Review
Title: Hyaluronic Acid as Polymeric Carrier of Drugs and Proteins
Authors: Monica Campisi 1 and Anna Mero 2
Affiliation: 1 Fidia Farmaceutici, Via Ponte della Fabbrica 3/A, 35031 Abano Terme, Italy;
2 Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131, Padova, Italy; E-mail: email@example.com
Abstract: Hyaluronic acid (HA) has currently several therapeutic applications, such as in ophthalmology, osteoarthritis, wound healing, tissue regeneration, postoperative antiadhesion, aesthetic medicine. In the last ten years it has also been successfully investigated in the field of drug delivery, in the form of conjugates or hydrogel depot systems. HAylation, the covalent conjugation of HA to bioactive molecules, allows the overcoming of disadvantages associated with some pharmaceuticals, such as insolubility, instability and fast kidney clearance. These issues can be addressed also by PEGylation but HA has the relevant advantages of biodegradability, high loading and specific targeting. In this review, it will be discussed the novel HA derivatives and the latest advances in HA-based drug delivery with a particular focus on the chemistry of conjugation. Although so far there are not HA-drug conjugates on the market, several derivatives are presently under clinical investigation and the promising results encourage further investigations and the exploitation of this versatile polysaccharide.
Type of Paper: Review
Title: Polypeptide-based Polymer Therapeutics
Authors: Aroa Duro Castaño, Inma Conejos Sanchez and Maria Jesus Vicent
Affiliation: Polymer Therapeutics Lab, Centro de Investigación Príncipe Felipe, Av. Eduardo Primo Yúfera 3, 46012 valencia, Spain; E-Mail: firstname.lastname@example.org
Abstract: Polypeptides are envisaged to achieve a major impact on a number of different relevant areas such as biomedicine and biotechnology. Acquired knowledge and the increasing interest on amino acids, peptides and proteins is establishing a large panel of these biopolymers whose physical, chemical and biological properties derived from their controlled sequences and composition. Polymer Therapeutics has turnover these polypeptide-based systems focused on the design of polymeric nanomedicines towards different biological applications such as disease treatment and diagnostics. Herein we overview the advantages of these systems and the main methodologies for their synthesis, highlighting the different polypeptide architectures and the current research for biomedical output within the field.
Type of Paper: Review
Title: Polymers for Protein Conjugation
Author: Gianfranco Pasut
Affiliation: Dept. Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131, Padova, Italy; E-Mail: email@example.com
Abstract: PEG has so far represented the leading polymer in the field of polymer-protein conjugation, thanks both to its unique properties and the well-known low toxic profile in humans, supported by a long history of experimentations. Nevertheless, new polymers are emerging as potential candidates for protein conjugation and they should represent a forward step towards a safe, biodegradable and tailor-made conjugating polymer. This review will focus on the most relevant polymers proposed for this aim of protein delivery.
Title: Impact of the EPR effect and the enzyme levels on the activity of polymer-drug conjugates
Authors: Rajora A., Ravishankar D., Osborn H. and Greco F.*
Affiliation: School of Pharmacy, Reading, UK, E-mail: firstname.lastname@example.org
Abstract: Polymer-drug conjugates are the nanomedicines designed to achieve tumour selectivity within the context of for cancer therapy. In past two decades, several polymer-drug conjugates have reached clinical trials but none has yet reached the market. Generally, these conjugates rely on the enhance permeability and retention (EPR) effect for tumour targeting and on the presence of specific enzymes (such as cathepsin B) for drug release. In this paper we aim to investigate if a correlation can be observed between enzyme levels and EPR effect at the desire therapeutic sites with the patient responses to polymer-drug conjugates.
Type of Paper: Review
Title: “Polymers for drug release in OA joints; clinical needs and opportunities”
Author: Maarten Janssen
Affiliation: Department of Orthopedic Surgery, Maastricht University Medical Center, Maastricht, the Netherlands; E-Mail: email@example.com
Abstract: Osteoarthritis (OA) is big burden of disease worldwide and one of the most common causes of disability in the adult population. Currently applied therapies consist of physical therapy, oral medication, intra-articular injections and surgical interventions with the main goal to reduce pain and improve function and quality of life.Intra-articular (IA) administration of drugs has potential benefits in OA treatment because it minimizes systemic bioavailability and side effects associated with oral administration of drugs without compromising the therapeutic effect in the joint.
However IA drug residence time is short and there is a clinical need for a vehicle that is able to provide a sustained release long enough for IA therapy to fulfill its promise.
This review summarizes the use of different polymers and the drugs encapsulated for IA drug delivery in the osteoarthritic joint with a primary focus on clinical needs and opportunities.
Last update: 23 October 2013