Special Issue "Polymers for Drug Delivery"
A special issue of Polymers (ISSN 2073-4360).
Deadline for manuscript submissions: closed (30 November 2013)
Prof. Dr. Gianfranco Pasut
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, Padova 35131, Italy
Fax: +39 049 827 5366
Interests: polymer-drug and polymer-protein conjugates; PEGylation; enzymatic conjugation; site-selective polymer conjugation; enzymatic conjugation; tumor targeted anticancer conjugates; conjugates for combination therapy; hyaluronic acid as drug carrier; stealth liposomes
Polymers have performed and will continue to play a central role in drug delivery. These macromolecules are now being used in several drug delivery approaches (e.g., drug and protein conjugates, micro and nanoparticles, nanocapsules, matrices and hydrogels, polymersomes, complexing polymers etc.) or are themselves drugs (e.g., polymers for molecular sequestration). Polymers have, moreover, also been exploited to improve the performance of other drug delivery systems (e.g., stealth liposomes). In view of this vast scenario of applications, researchers continue to propose new polymers characterized by improved features and biocompatibility as well as innovative applications. Some have also been designed to successfully replace the current gold standard for stealth coatings, polyethylene glycol (PEG). The sum of these research activities has yielded a growing number of polymer-based products that have been approved by regulatory authorities or are under investigation in clinical trials.
Relevant, “smart” carriers are needed to recapture the interest of the pharmaceutical industry which has the means to cover research costs to develop new polymers for human use. Collaboration between academia and the pharmaceutical industry must be promoted if research findings in the laboratory are to be taken to the bedside. As researchers design new studies in this field, it is important that they address vital issues such as reproducible synthesis, biodegradability of polymers, elimination pathways, biocompatibility, storage stability, polydispersity, polymer characterization methods, feasibility of selective chemical modification, etc.
This issue aims to review the current state-of-the-art concerning polymeric drug delivery systems and to envision future perspectives. The topical subjects to be addressed include: synthetic polymers, natural polymers, bioconjugation of polymers, smart polymers, amphiphilic polymers, bioactive polymers, the dynamics of polymers crossing biological barriers, targeted drug delivery, polymers as drugs, etc.
Prof. Dr. Gianfranco Pasut
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed Open Access monthly journal published by MDPI.
- drug delivery
- bio-responsive polymers
- biocompatible polymers
- amphiphilic polymers
- smart polymers