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Polymers 2014, 6(3), 755-775; doi:10.3390/polym6030755

Local Delivery of Antiproliferative Agents via Stents

Received: 2 December 2013 / Revised: 10 February 2014 / Accepted: 25 February 2014 / Published: 12 March 2014
(This article belongs to the Special Issue Polymers for Drug Delivery)
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A stent is a medical device for serving as an internal scaffold to maintain or increase the lumen of a body conduit. Stent placement has become a primary treatment option in coronary artery disease for more than the last two decades. The stenting is also currently used for relieving the symptoms of narrowed lumen of nonvascular organs, such as esophagus, trachea and bronchi, small and large intestines, biliary, and urinary tract. Local delivery of active pharmaceutical agents via the stents can not only enhance healing of certain diseases, but it can also help decrease the potential risk of the stenting procedure to the surrounding tissue. In this review, we focus on reviewing a variety of drug-impregnated stents and local drug delivery systems using the stents.
Keywords: vascular stent; nonvascular stent; e-PTFE; silicone; polyurethane; paclitaxel; gemcitabine; siRNA vascular stent; nonvascular stent; e-PTFE; silicone; polyurethane; paclitaxel; gemcitabine; siRNA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kwon, H.J.; Park, S. Local Delivery of Antiproliferative Agents via Stents. Polymers 2014, 6, 755-775.

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