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Peptide-Based Polymer Therapeutics
Polymer Therapeutics Lab., Centro de Investigación Príncipe Felipe, Av. Eduardo Primo Yúfera 3, Valencia 46012, Spain
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 28 December 2013; in revised form: 6 February 2014 / Accepted: 7 February 2014 / Published: 21 February 2014
Abstract: Polypeptides are envisaged to achieve a major impact on a number of different relevant areas such as biomedicine and biotechnology. Acquired knowledge and the increasing interest on amino acids, peptides and proteins is establishing a large panel of these biopolymers whose physical, chemical and biological properties are ruled by their controlled sequences and composition. Polymer therapeutics has helped to establish these polypeptide-based constructs as polymeric nanomedicines for different applications, such as disease treatment and diagnostics. Herein, we provide an overview of the advantages of these systems and the main methodologies for their synthesis, highlighting the different polypeptide architectures and the current research towards clinical applications.
Keywords: polymer therapeutics; polypeptides; drug delivery; nanomedicine
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Duro-Castano, A.; Conejos-Sánchez, I.; Vicent, M.J. Peptide-Based Polymer Therapeutics. Polymers 2014, 6, 515-551.
Duro-Castano A, Conejos-Sánchez I, Vicent MJ. Peptide-Based Polymer Therapeutics. Polymers. 2014; 6(2):515-551.
Duro-Castano, Aroa; Conejos-Sánchez, Inmaculada; Vicent, María J. 2014. "Peptide-Based Polymer Therapeutics." Polymers 6, no. 2: 515-551.