Polymers 2014, 6(3), 890-898; doi:10.3390/polym6030890
Article

Preparation of Poly(acrylic acid) Hydrogel by Radiation Crosslinking and Its Application for Mucoadhesives

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Received: 8 January 2014; in revised form: 7 March 2014 / Accepted: 13 March 2014 / Published: 19 March 2014
(This article belongs to the Special Issue Polymers for Drug Delivery)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A mucoadhesive drug delivery system can improve the effectiveness of a drug by maintaining the drug concentration and allowing targeting and localization of the drug at a specific site. Acrylic-based hydrogels have been used extensively as a mucoadhesive system owing to their flexibility and excellent bioadhesion. In this experiment, poly(acrylic acid) was selected to prepare the bioadhesive hydrogel adhering to mucosal surfaces using a radiation process. Poly(acrylic acid) was dissolved in water to a prepare poly(acrylic acid) solution, and the solution was then irradiated by an electron beam at up to 75 kGy to make hydrogels. Their physical properties, such as gel percent, swelling percent and adhesive strength to mucosal surfaces, were investigated. Triamcinolone acetonide was used as a model drug. The dried poly(acrylic acid) film was dipped in a 0.1 wt% triamcinolone acetonide solution in ethanol, and then dried at 25 °C. The release of triamcinolone acetonide was determined at different time intervals, and UV (Ultraviolet)-Vis spectroscopy was used to determine the released concentration of triamcinolone acetonide at 238 nm. It was shown that poly(acrylic acid)-based drug carriers were successfully prepared for use in a bioadhesive drug delivery system.
Keywords: mucoadhesive; oral cavity; drug carriers; poly acrylic acid (PAA); electron beam; irradiation
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MDPI and ACS Style

Nho, Y.-C.; Park, J.-S.; Lim, Y.-M. Preparation of Poly(acrylic acid) Hydrogel by Radiation Crosslinking and Its Application for Mucoadhesives. Polymers 2014, 6, 890-898.

AMA Style

Nho Y-C, Park J-S, Lim Y-M. Preparation of Poly(acrylic acid) Hydrogel by Radiation Crosslinking and Its Application for Mucoadhesives. Polymers. 2014; 6(3):890-898.

Chicago/Turabian Style

Nho, Young-Chang; Park, Jong-Seok; Lim, Youn-Mook. 2014. "Preparation of Poly(acrylic acid) Hydrogel by Radiation Crosslinking and Its Application for Mucoadhesives." Polymers 6, no. 3: 890-898.

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