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Polymers 2014, 6(1), 243-260; doi:10.3390/polym6010243

Biocompatibility of Poly(ester amide) (PEA) Microfibrils in Ocular Tissues

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Received: 30 November 2013 / Revised: 10 January 2014 / Accepted: 13 January 2014 / Published: 21 January 2014
(This article belongs to the Special Issue Polymers for Drug Delivery)
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Abstract: Drug delivery systems (DDS) are able to deliver, over long periods of time, therapeutic concentrations of drugs requiring frequent administration. Two classes of DDS are available, biodegradable and non-biodegradable. The larger non-biodegradable implants ensure long-term delivery, but require surgical interventions. Biodegradable biomaterials are smaller, injectable implants, but degrade hydrolytically and release drugs in non-zero order kinetics, which is inefficient for long-term sustained drug release. Biodegradable poly(ester amides) (PEAs) may overcome these difficulties. To assess their ocular biocompatibility and long-term behavior, PEA fibrils were analyzed in vitro and in vivo. In vitro, incubation in vitreous humor changes to PEA structure, suggests degradation by surface erosion, enabling drug release with zero order kinetics. Clinical and histological analysis of PEA fibrils implanted subconjunctivally and intravitreally showed the absence of an inflammatory response or other pathological tissue alteration. This study shows that PEA fibrils are biocompatible with ocular environment and degrade by surface erosion.
Keywords: biomaterials; biodegradation; drug delivery; controlled drug release; amino acid biomaterials; biodegradation; drug delivery; controlled drug release; amino acid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kropp, M.; Morawa, K.-M.; Mihov, G.; Salz, A.K.; Harmening, N.; Franken, A.; Kemp, A.; Dias, A.A.; Thies, J.; Johnen, S.; Thumann, G. Biocompatibility of Poly(ester amide) (PEA) Microfibrils in Ocular Tissues. Polymers 2014, 6, 243-260.

AMA Style

Kropp M, Morawa K-M, Mihov G, Salz AK, Harmening N, Franken A, Kemp A, Dias AA, Thies J, Johnen S, Thumann G. Biocompatibility of Poly(ester amide) (PEA) Microfibrils in Ocular Tissues. Polymers. 2014; 6(1):243-260.

Chicago/Turabian Style

Kropp, Martina; Morawa, Katharina-Marie; Mihov, George; Salz, Anna K.; Harmening, Nina; Franken, Astrid; Kemp, Anja; Dias, Aylvin A.; Thies, Jens; Johnen, Sandra; Thumann, Gabriele. 2014. "Biocompatibility of Poly(ester amide) (PEA) Microfibrils in Ocular Tissues." Polymers 6, no. 1: 243-260.

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