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Polymers 2014, 6(3), 799-819; doi:10.3390/polym6030799

Drugs and Polymers for Delivery Systems in OA Joints: Clinical Needs and Opportunities

Department of Orthopaedic Surgery, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX Maastricht, the Netherlands
DSM Biomedical, Koestraat 1, 6167 RA Geleen, the Netherlands
Author to whom correspondence should be addressed.
Received: 31 January 2014 / Revised: 2 March 2014 / Accepted: 3 March 2014 / Published: 13 March 2014
(This article belongs to the Special Issue Polymers for Drug Delivery)
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Osteoarthritis (OA) is a big burden of disease worldwide and one of the most common causes of disability in the adult population. Currently applied therapies consist of physical therapy, oral medication, intra-articular injections, and surgical interventions, with the main goal being to reduce pain and improve function and quality of life. Intra-articular (IA) administration of drugs has potential benefits in OA treatment because it minimizes systemic bioavailability and side effects associated with oral administration of drugs without compromising the therapeutic effect in the joint. However, IA drug residence time is short and there is a clinical need for a vehicle that is able to provide a sustained release long enough for IA therapy to fulfill its promise. This review summarizes the use of different polymeric systems and the incorporated drugs for IA drug delivery in the osteoarthritic joint with a primary focus on clinical needs and opportunities.
Keywords: osteoarthritis; drug delivery systems; DMOAD osteoarthritis; drug delivery systems; DMOAD
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Janssen, M.; Mihov, G.; Welting, T.; Thies, J.; Emans, P. Drugs and Polymers for Delivery Systems in OA Joints: Clinical Needs and Opportunities. Polymers 2014, 6, 799-819.

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