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Polymers 2014, 6(1), 160-178; doi:10.3390/polym6010160
Review

Polymers for Protein Conjugation

Pharmaceutical and Pharmacological Sciences Department, University of Padova, Via F. Marzolo 5, Padova 35131, Italy
Received: 3 December 2013 / Revised: 30 December 2013 / Accepted: 7 January 2014 / Published: 13 January 2014
(This article belongs to the Special Issue Polymers for Drug Delivery)
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Abstract

Polyethylene glycol (PEG) at the moment is considered the leading polymer for protein conjugation in view of its unique properties, as well as to its low toxicity in humans, qualities which have been confirmed by its extensive use in clinical practice. Other polymers that are safe, biodegradable and custom-designed have, nevertheless, also been investigated as potential candidates for protein conjugation. This review will focus on natural polymers and synthetic linear polymers that have been used for protein delivery and the results associated with their use. Genetic fusion approaches for the preparation of protein-polypeptide conjugates will be also reviewed and compared with the best known chemical conjugation ones.
Keywords: protein delivery; PEGylation; polymer conjugation; dextran; hyaluronic acid; polysialic acid; dextrin; poly(2-ethyl 2-oxazoline) protein delivery; PEGylation; polymer conjugation; dextran; hyaluronic acid; polysialic acid; dextrin; poly(2-ethyl 2-oxazoline)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pasut, G. Polymers for Protein Conjugation. Polymers 2014, 6, 160-178.

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