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RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells
Polymer Competence Center Leoben GmbH PCCL, Roseggerstrasse 12, Leoben 8700, Austria
Institute for Chemistry and Technology of Materials, Graz University of Technology, Stremayrgasse 9, Graz 8010, Austria
Institute of Physiology, Charité, Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, Berlin 10117, Germany
These authors share the last authorship.
* Authors to whom correspondence should be addressed.
Received: 16 November 2013; in revised form: 8 January 2014 / Accepted: 15 January 2014 / Published: 27 January 2014
Abstract: Poly(2-oxazoline) networks with varying swelling degrees and varying hydrophilicity can be synthesized from 2-ethyl-2-oxazoline, 2-nonyl-2-oxazoline, 2-9’-decenyl-2-oxazoline and 2,2’-tetramethylene-bis-2-oxazoline in one-pot/one-step strategies. These gels can be loaded with organic molecules, such as fluorescein isothiocyanate, either during the polymerization (covalent attachment of the dye) or according to post-synthetic swelling/deswelling strategies (physical inclusion of the dye). Surface functionalization of ground gels by thiol-ene reactions with cysteine-bearing peptides exhibiting the arginine-glycine-aspartic acid (RGD) motif yields microparticles with enhanced recognition of human cancer cells compared to healthy endothelial cells.
Keywords: poly(2-oxazoline)s; crosslinked polymer networks; RGD interaction with integrins; cancer cell recognition
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MDPI and ACS Style
Schenk, V.; Rossegger, E.; Ebner, C.; Bangerl, F.; Reichmann, K.; Hoffmann, B.; Höpfner, M.; Wiesbrock, F. RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells. Polymers 2014, 6, 264-279.
Schenk V, Rossegger E, Ebner C, Bangerl F, Reichmann K, Hoffmann B, Höpfner M, Wiesbrock F. RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells. Polymers. 2014; 6(2):264-279.
Schenk, Verena; Rossegger, Elisabeth; Ebner, Clemens; Bangerl, Florian; Reichmann, Klaus; Hoffmann, Björn; Höpfner, Michael; Wiesbrock, Frank. 2014. "RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells." Polymers 6, no. 2: 264-279.