Polymers 2014, 6(2), 264-279; doi:10.3390/polym6020264
Article

RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells

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Received: 16 November 2013; in revised form: 8 January 2014 / Accepted: 15 January 2014 / Published: 27 January 2014
(This article belongs to the Special Issue Polymers for Drug Delivery)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Poly(2-oxazoline) networks with varying swelling degrees and varying hydrophilicity can be synthesized from 2-ethyl-2-oxazoline, 2-nonyl-2-oxazoline, 2-9’-decenyl-2-oxazoline and 2,2’-tetramethylene-bis-2-oxazoline in one-pot/one-step strategies. These gels can be loaded with organic molecules, such as fluorescein isothiocyanate, either during the polymerization (covalent attachment of the dye) or according to post-synthetic swelling/deswelling strategies (physical inclusion of the dye). Surface functionalization of ground gels by thiol-ene reactions with cysteine-bearing peptides exhibiting the arginine-glycine-aspartic acid (RGD) motif yields microparticles with enhanced recognition of human cancer cells compared to healthy endothelial cells.
Keywords: poly(2-oxazoline)s; crosslinked polymer networks; RGD interaction with integrins; cancer cell recognition
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MDPI and ACS Style

Schenk, V.; Rossegger, E.; Ebner, C.; Bangerl, F.; Reichmann, K.; Hoffmann, B.; Höpfner, M.; Wiesbrock, F. RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells. Polymers 2014, 6, 264-279.

AMA Style

Schenk V, Rossegger E, Ebner C, Bangerl F, Reichmann K, Hoffmann B, Höpfner M, Wiesbrock F. RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells. Polymers. 2014; 6(2):264-279.

Chicago/Turabian Style

Schenk, Verena; Rossegger, Elisabeth; Ebner, Clemens; Bangerl, Florian; Reichmann, Klaus; Hoffmann, Björn; Höpfner, Michael; Wiesbrock, Frank. 2014. "RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells." Polymers 6, no. 2: 264-279.

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