Polymers 2014, 6(2), 264-279; doi:10.3390/polym6020264
Article

RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells

1 Polymer Competence Center Leoben GmbH PCCL, Roseggerstrasse 12, Leoben 8700, Austria 2 Institute for Chemistry and Technology of Materials, Graz University of Technology, Stremayrgasse 9, Graz 8010, Austria 3 Institute of Physiology, Charité, Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, Berlin 10117, Germany These authors share the last authorship.
* Authors to whom correspondence should be addressed.
Received: 16 November 2013; in revised form: 8 January 2014 / Accepted: 15 January 2014 / Published: 27 January 2014
(This article belongs to the Special Issue Polymers for Drug Delivery)
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Abstract: Poly(2-oxazoline) networks with varying swelling degrees and varying hydrophilicity can be synthesized from 2-ethyl-2-oxazoline, 2-nonyl-2-oxazoline, 2-9’-decenyl-2-oxazoline and 2,2’-tetramethylene-bis-2-oxazoline in one-pot/one-step strategies. These gels can be loaded with organic molecules, such as fluorescein isothiocyanate, either during the polymerization (covalent attachment of the dye) or according to post-synthetic swelling/deswelling strategies (physical inclusion of the dye). Surface functionalization of ground gels by thiol-ene reactions with cysteine-bearing peptides exhibiting the arginine-glycine-aspartic acid (RGD) motif yields microparticles with enhanced recognition of human cancer cells compared to healthy endothelial cells.
Keywords: poly(2-oxazoline)s; crosslinked polymer networks; RGD interaction with integrins; cancer cell recognition

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MDPI and ACS Style

Schenk, V.; Rossegger, E.; Ebner, C.; Bangerl, F.; Reichmann, K.; Hoffmann, B.; Höpfner, M.; Wiesbrock, F. RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells. Polymers 2014, 6, 264-279.

AMA Style

Schenk V, Rossegger E, Ebner C, Bangerl F, Reichmann K, Hoffmann B, Höpfner M, Wiesbrock F. RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells. Polymers. 2014; 6(2):264-279.

Chicago/Turabian Style

Schenk, Verena; Rossegger, Elisabeth; Ebner, Clemens; Bangerl, Florian; Reichmann, Klaus; Hoffmann, Björn; Höpfner, Michael; Wiesbrock, Frank. 2014. "RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells." Polymers 6, no. 2: 264-279.

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