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Polymers 2014, 6(2), 264-279; doi:10.3390/polym6020264

RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells

1
Polymer Competence Center Leoben GmbH PCCL, Roseggerstrasse 12, Leoben 8700, Austria
2
Institute for Chemistry and Technology of Materials, Graz University of Technology, Stremayrgasse 9, Graz 8010, Austria
3
Institute of Physiology, Charité, Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, Berlin 10117, Germany
These authors share the last authorship.
*
Authors to whom correspondence should be addressed.
Received: 16 November 2013 / Revised: 8 January 2014 / Accepted: 15 January 2014 / Published: 27 January 2014
(This article belongs to the Special Issue Polymers for Drug Delivery)
View Full-Text   |   Download PDF [3646 KB, 29 January 2014; original version 27 January 2014]   |  

Abstract

Poly(2-oxazoline) networks with varying swelling degrees and varying hydrophilicity can be synthesized from 2-ethyl-2-oxazoline, 2-nonyl-2-oxazoline, 2-9’-decenyl-2-oxazoline and 2,2’-tetramethylene-bis-2-oxazoline in one-pot/one-step strategies. These gels can be loaded with organic molecules, such as fluorescein isothiocyanate, either during the polymerization (covalent attachment of the dye) or according to post-synthetic swelling/deswelling strategies (physical inclusion of the dye). Surface functionalization of ground gels by thiol-ene reactions with cysteine-bearing peptides exhibiting the arginine-glycine-aspartic acid (RGD) motif yields microparticles with enhanced recognition of human cancer cells compared to healthy endothelial cells. View Full-Text
Keywords: poly(2-oxazoline)s; crosslinked polymer networks; RGD interaction with integrins; cancer cell recognition poly(2-oxazoline)s; crosslinked polymer networks; RGD interaction with integrins; cancer cell recognition
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Schenk, V.; Rossegger, E.; Ebner, C.; Bangerl, F.; Reichmann, K.; Hoffmann, B.; Höpfner, M.; Wiesbrock, F. RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells. Polymers 2014, 6, 264-279.

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