Special Issue "Protein-Carbohydrate Interactions"
Deadline for manuscript submissions: closed (30 May 2017)
Prof. Dr. Roland J. Pieters
Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, Utrecht, The Netherlands
Website | E-Mail
Interests: protein-carbohydrate interactions; lectins; glycosidases; carbohydrate microarrays; multivalency; bacterial adhesion; viral adhesion; O-GlcNAcylation
Protein–carbohydrate interactions play important roles in biological processes. On the surface of cells, carbohydrates communicate information to the outside, and, for example, are of importance in the immune system. In addition to on the cell surface, inside the cell, O-GlcNAcylation of proteins is of great importance in cell regulation. In most cases, the recognition of carbohydrates is performed by carbohydrate-recognizing proteins, such as lectins, but also antibodies and carbohydrate processing enzymes. In many cases, protein carbohydrate recognition is responsible for disease, for example, through adhesion of microbial pathogens or toxins. In addition to this, carbohydrates and complementary proteins also provide opportunities to treat numerous diseases, for example, in the immune system and cancer.
In order to better understand the biology and communication aspects of protein carbohydrate recognition, new selective bioactive molecules need to be explored, such as enzyme inhibitors based on close transition state mimicry, bisubstrate inhibitors, and adhesion inhibitors. In addition to the better understanding such molecules will yield, medicinal applications may also come within reach. Thus far, few drugs based on carbohydrates have made it to market. Nevertheless, the hurdles, such as the lack of oral availability, renal excretion, and degradation and weak binding, have all been overcome in select cases. Approaches, such as glycomimetics, prodrugs, and binding to plasma proteins, can help the drug properties of carbohydrate derivatives, while multivalency can enhance the binding affinities. In this Special Issue, we welcome contributions in all mentioned areas, as well as those reporting on novel tools to study protein–carbohydrate interactions, as well as the application of computational tools.
Prof. Dr. Roland Pieters
Manuscript Submission Information
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- protein–carbohydrate interactions
- glycosyl transferases
- carbohydrate microarrays
- bacterial adhesion
- viral adhesion