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Special Issue "Oligonucleotides Application to Nano- and Biotechnology (DNA Origami, DNA Machine)"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 30 June 2018

Special Issue Editors

Guest Editor
Prof. Dr. Shigeki Sasaki

Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Website | E-Mail
Interests: functional oligonucleotides; therapeutic oligonucleotide; medicinal chemistry; drug delivery; molecular therapy; nano-medicine
Guest Editor
Dr. Marcel Hollenstein

Laboratory for Bioorganic Chemistry of Nucleic Acids, Department of Structural Biology and Chemistry, Institut Pasteur, CNRS UMR3523, 28, rue du Docteur Roux, 75724 Paris Cedex 15, France
Website | E-Mail
Interests: synthesis of modified nucleoside triphosphates and nucleoside analogues for their use in selection experiments to isolate aptamers and catalytic nucleic acids for their application as imaging and therapeutic agents; enzymatic construction of artificial metal base-pairs for an expansion of the genetic code

Special Issue Information

Dear Colleagues,

Progress in organic synthesis, molecular biology, and nanotechnology has made nucleic acids leading elements in numerous applications. For instance, DNA oligonucleotides are the fundamental building elements for the construction of DNA origamis, nanodevices, and nanomachines. Oligonucleotides are also essential in the development of the antisense therapy strategy and other related gene silencing methods. Conjugation of oligonucleotides to other biopolymers and/or chemical entities, such as cell penetrating peptides or metal complexes is a highly developing field of research. Lastly, the advent of SELEX has made aptamers and DNAzymes popular tools for biosensing and therapeutic applications and the inclusion of modified triphosphates broadens the scope of these functional nucleic acids. Therefore, in this Special Issue on oligonucleotides, we welcome research articles and comprehensive reviews in all mentioned areas.

Prof. Dr. Shigeki Sasaki
Dr. Marcel Hollenstein
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • DNA nanotechnology
  • aptamers
  • DNAzymes
  • oligonucleotide sensors
  • antisense oligonucleotides
  • therapeutic oligonucleotides
  • modified nucleoside triphosphates
  • modified oligonucleotides
  • synthesis of oligonucleotides
  • oligonucleotide conjugates

Published Papers

This special issue is now open for submission.
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