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Molecules 2018, 23(7), 1766; https://doi.org/10.3390/molecules23071766

DNA Origami Nanomachines

Department of Chemistry, Graduate School of Science, and Institute for Integrated Cell-Material Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
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Received: 5 July 2018 / Accepted: 17 July 2018 / Published: 18 July 2018
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Abstract

DNA can assemble various molecules and nanomaterials in a programmed fashion and is a powerful tool in the nanotechnology and biology research fields. DNA also allows the construction of desired nanoscale structures via the design of DNA sequences. Structural nanotechnology, especially DNA origami, is widely used to design and create functionalized nanostructures and devices. In addition, DNA molecular machines have been created and are operated by specific DNA strands and external stimuli to perform linear, rotational, and reciprocating movements. Furthermore, complicated molecular systems have been created on DNA nanostructures by arranging multiple molecules and molecular machines precisely to mimic biological systems. Currently, DNA nanomachines, such as molecular motors, are operated on DNA nanostructures. Dynamic DNA nanostructures that have a mechanically controllable system have also been developed. In this review, we describe recent research on new DNA nanomachines and nanosystems that were built on designed DNA nanostructures. View Full-Text
Keywords: DNA nanotechnology; DNA origami; DNA nanomachine; single-molecule analysis; high-speed AFM DNA nanotechnology; DNA origami; DNA nanomachine; single-molecule analysis; high-speed AFM
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Endo, M.; Sugiyama, H. DNA Origami Nanomachines. Molecules 2018, 23, 1766.

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