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Molecules 2018, 23(9), 2267; https://doi.org/10.3390/molecules23092267

Oligonucleotides Targeting Telomeres and Telomerase in Cancer

Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107, USA
These authors contributed equally to this work.
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Academic Editors: Shigeki Sasaki and Marcel Hollenstein
Received: 26 July 2018 / Revised: 27 August 2018 / Accepted: 4 September 2018 / Published: 5 September 2018
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Abstract

Telomeres and telomerase have become attractive targets for the development of anticancer therapeutics due to their involvement in cancer cell immortality. Currently, several therapeutics have been developed that directly target telomerase and telomeres, such as telomerase inhibitors and G-quadruplex stabilizing ligands. Telomere-specific oligonucleotides that reduce telomerase activity and disrupt telomere architecture are also in development as novel anticancer therapeutics. Specifically, GRN163L and T-oligos have demonstrated promising anticancer activity in multiple cancers types via induction of potent DNA damage responses. Currently, several miRNAs have been implicated in the regulation of telomerase activity and may prove to be valuable targets in the development of novel therapies by reducing expression of telomerase subunits. Targeting miRNAs that are known to increase expression of telomerase subunits may be another strategy to reduce carcinogenesis. This review aims to provide a comprehensive understanding of current oligonucleotide-based anticancer therapies that target telomeres and telomerase. These studies may help design novel therapeutic approaches to overcome the challenges of oligonucleotide therapy in a clinical setting. View Full-Text
Keywords: T-oligo; GRN163L; miRNA; imetelstat; telomere; telomerase T-oligo; GRN163L; miRNA; imetelstat; telomere; telomerase
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Schrank, Z.; Khan, N.; Osude, C.; Singh, S.; Miller, R.J.; Merrick, C.; Mabel, A.; Kuckovic, A.; Puri, N. Oligonucleotides Targeting Telomeres and Telomerase in Cancer. Molecules 2018, 23, 2267.

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