Special Issue "Intramolecular Hydrogen Bonding"


A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: closed (30 June 2014)

Special Issue Editor

Guest Editor
Prof. Dr. Ronald K. Castellano
Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL 32611, USA
Website: http://www.chem.ufl.edu/~castellano/
E-Mail: castellano@chem.ufl.edu
Phone: +1 352 392 2752
Fax: +1 352 846 0296
Interests: aromatic interactions; bio-inspired electronic materials; donor-acceptor interactions; hydrogen bonding; noncovalent interactions; organic light emitting devices; organic synthesis; photophysical properties; organic photovoltaics; pi-conjugated materials; self-assembly; supramolecular chemistry; synthesis of multifunctional molecules

Special Issue Information

Dear Colleagues,

Intramolecular hydrogen bonds play critical structure- and function-serving roles in biological and synthetic molecular systems. In many cases, the interactions are strong enough to influence molecular and supramolecular structure over long time scales and in diverse solvent or solid-state environments. Classic examples come from biological and biomimetic (e.g., self-folding) molecules that rely on intramolecular hydrogen bonds in water to stabilize the functional secondary and tertiary structure. In other settings, they subtly affect conformational dynamics or competing transition state energetics. The utility of these interactions in catalysis, particularly organocatalysis, continues to gain appreciation among synthetic practitioners. With respect to the photophysical properties and electronic structures of molecules, intramolecular hydrogen bonds are now used routinely to enforce the planarization of π-conjugated materials and enjoy an important role in excited state intramolecular proton transfer processes and associated photochromic, thermochromic, and sensing applications. For supramolecular chemists, these interactions underpin a standard strategy to “preorganize” hosts for guest binding. Our ability to rationally deploy intramolecular hydrogen bonds in molecular design is linked to how well they are fundamentally understood. Along these lines, significant advances have been made over recent years to delineate the energetic and spectroscopic features of the interactions through experimental and theoretical methods. Research papers dealing with all aspects of intramolecular hydrogen bonding, from theory to experiment, and from physical characterization to synthetic application, are welcomed for inclusion into this Special Issue of Molecules. Review articles, particularly those emphasizing the unique structural or functional aspects of intramolecular hydrogen bonding, are also encouraged.

Prof. Dr. Ronald K. Castellano
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).


  • biomolecular structure
  • catalysis
  • conformation
  • crystal engineering
  • excited state intramolecular proton transfer
  • host-guest complexes
  • intramolecular hydrogen bonding
  • low-barrier hydrogen bonds
  • peptidomimetics
  • photophysical properties
  • resonance-assisted hydrogen bonding
  • sensors
  • spectroscopic characterization of intramolecular hydrogen bonds
  • supramolecular chemistry
  • tautomerism
  • theoretical investigation of intramolecular hydrogen bonds
  • unconventional hydrogen bonds

Published Papers (5 papers)

by , , ,  and
Molecules 2014, 19(9), 13282-13304; doi:10.3390/molecules190913282
Received: 7 July 2014; in revised form: 8 August 2014 / Accepted: 20 August 2014 / Published: 28 August 2014
Show/Hide Abstract | PDF Full-text (2177 KB) | Supplementary Files

by , , , , ,  and
Molecules 2014, 19(8), 12852-12880; doi:10.3390/molecules190812852
Received: 1 July 2014; in revised form: 12 August 2014 / Accepted: 13 August 2014 / Published: 21 August 2014
Show/Hide Abstract | PDF Full-text (2104 KB) | Supplementary Files

by ,  and
Molecules 2014, 19(8), 11440-11452; doi:10.3390/molecules190811440
Received: 23 June 2014; in revised form: 20 July 2014 / Accepted: 23 July 2014 / Published: 4 August 2014
Show/Hide Abstract | PDF Full-text (1567 KB)

by , , ,  and
Molecules 2014, 19(8), 11316-11332; doi:10.3390/molecules190811316
Received: 28 April 2014; in revised form: 23 July 2014 / Accepted: 24 July 2014 / Published: 31 July 2014
Show/Hide Abstract | PDF Full-text (2047 KB)
abstract graphic

by , ,  and
Molecules 2014, 19(7), 9354-9368; doi:10.3390/molecules19079354
Received: 9 May 2014; in revised form: 18 June 2014 / Accepted: 27 June 2014 / Published: 3 July 2014
Show/Hide Abstract | PDF Full-text (1081 KB) | HTML Full-text | XML Full-text | Supplementary Files
abstract graphic

Last update: 18 July 2014

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