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Special Issue "Hyaluronic Acid and its Derivatives for Biomedical Applications"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 15 March 2019

Special Issue Editor

Guest Editor
Prof. Dr. Silvia Arpicco

Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Via P. Giuria 9, 10125 Torino, Italy
Website | E-Mail
Interests: drug targeting; actively targeted drug delivery systems; liposomes; nanoparticles; hyaluronic acid; anticancer drugs

Special Issue Information

Dear Colleagues,

In the last few decades, hyaluronic acid (HA) has been widely used in the biomedical and pharmaceutical field. Thanks to its favorable physicochemical and biological properties, including biocompatibility, biodegradability, nonimmunogenicity, HA has been employed as such or as a starting material for different purposes and in several therapeutic fields, such as fabrication of matrices and devices for tissue engineering, drug delivery, imaging, or surgical applications. The use of HA continues to grow; thus, this Special Issue aims to provide the state of the art and the dissemination of the latest information on new approaches and methods dealing with the preparation, characterization, and use of HA-based materials. I encourage authors to submit research papers and comprehensive reviews for this Special Issue.

Prof. Dr. Silvia Arpicco
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Hyaluronic acid
  • Drug delivery systems
  • Bioconjugates
  • Theranostic agents
  • Active targeting
  • Hydrogel
  • Topical drug delivery
  • Tissue engineering
  • Implantable biomaterials

Published Papers (4 papers)

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Research

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Open AccessArticle Charge-Controlled Synthetic Hyaluronan-Based Cell Matrices
Molecules 2018, 23(4), 769; https://doi.org/10.3390/molecules23040769
Received: 21 February 2018 / Revised: 22 March 2018 / Accepted: 23 March 2018 / Published: 27 March 2018
PDF Full-text (5739 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The extracellular matrix (ECM) represents a highly charged and hydrated network in which different cells in vertebrate tissues are embedded. Hydrogels as minimal ECM mimetics with a controlled chemistry offer the opportunity to vary material properties by varying the negative network charge. In
[...] Read more.
The extracellular matrix (ECM) represents a highly charged and hydrated network in which different cells in vertebrate tissues are embedded. Hydrogels as minimal ECM mimetics with a controlled chemistry offer the opportunity to vary material properties by varying the negative network charge. In this paper, a synthetic biology model of the ECM based on natural and highly negatively charged polyelectrolyte hyaluronic acid (HA) is characterized with specific emphasis on its charge-related bioactivity. Therefore, the thiol-Michael addition click reaction is used to produce HA hydrogels with defined network structure and charge density. The presented hydrogels show enzymatic degradability and cell attachment. These properties depend on both covalent and electrostatic interactions within the hydrogel network. Furthermore, no unspecific or specific attachment of proteins to the presented hydrogels is observed. In addition, these fundamental insights into charge-related ECM behavior and the influence of electrostatic properties could also lead to innovations in existing biomedical products. Full article
(This article belongs to the Special Issue Hyaluronic Acid and its Derivatives for Biomedical Applications)
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Graphical abstract

Open AccessArticle Thymosin α1 Interacts with Hyaluronic Acid Electrostatically by Its Terminal Sequence LKEKK
Molecules 2017, 22(11), 1843; https://doi.org/10.3390/molecules22111843
Received: 1 October 2017 / Revised: 19 October 2017 / Accepted: 24 October 2017 / Published: 27 October 2017
PDF Full-text (2240 KB) | HTML Full-text | XML Full-text
Abstract
Thymosin α1 (Tα1), is a peptidic hormone, whose immune regulatory properties have been demonstrated both in vitro and in vivo and approved in different countries for treatment of several viral infections and cancers. Tα1 assumes a conformation in negative membranes upon insertion into
[...] Read more.
Thymosin α1 (Tα1), is a peptidic hormone, whose immune regulatory properties have been demonstrated both in vitro and in vivo and approved in different countries for treatment of several viral infections and cancers. Tα1 assumes a conformation in negative membranes upon insertion into the phosphatidylserine exposure as found in several pathologies and in apoptosis. These findings are in agreement with the pleiotropy of Tα1, which targets both normal and tumor cells, interacting with multiple cellular components, and have generated renewed interest in the topic. Hyaluronan (HA) occurs ubiquitously in the extracellular matrix and on cell surfaces and has been related to a variety of diseases, and developmental and physiological processes. Proteins binding HA, among them CD44 and the Receptor for HA-mediated motility (RHAMM) receptors, mediate its biological effects. NMR spectroscopy indicated preliminarily that an interaction of Tα1 with HA occurs specifically around lysine residues of the sequence LKEKK of Tα1 and is suggestive of a possible interference of Tα1 in the binding of HA with CD44 and RHAMM. Further studies are needed to deepen these observations because Tα1 is known to potentiate the T-cell immunity and anti-tumor effect. The binding inhibitory activity of Tα1 on HA-CD44 or HA-RHAMM interactions can suppress both T-cell reactivity and tumor progression. Full article
(This article belongs to the Special Issue Hyaluronic Acid and its Derivatives for Biomedical Applications)
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Graphical abstract

Open AccessArticle Molecular Dynamic Analysis of Hyaluronic Acid and Phospholipid Interaction in Tribological Surgical Adjuvant Design for Osteoarthritis
Molecules 2017, 22(9), 1436; https://doi.org/10.3390/molecules22091436
Received: 13 July 2017 / Accepted: 25 August 2017 / Published: 4 September 2017
Cited by 2 | PDF Full-text (10122 KB) | HTML Full-text | XML Full-text
Abstract
Tribological surgical adjuvants constitute a therapeutic discipline made possible by surgical advances in the treatment of damaged articular cartilage beyond palliative care. The purpose of this study is to analyze interactions between hyaluronic acid and phospholipid molecules, and the formation of geometric forms,
[...] Read more.
Tribological surgical adjuvants constitute a therapeutic discipline made possible by surgical advances in the treatment of damaged articular cartilage beyond palliative care. The purpose of this study is to analyze interactions between hyaluronic acid and phospholipid molecules, and the formation of geometric forms, that play a role in the facilitated lubrication of synovial joint organ systems. The analysis includes an evaluation of the pathologic state to detail conditions that may be encountered by adjuvants during surgical convalescence. The synovial fluid changes in pH, hyaluronic acid polydispersity, and phospholipid concentration associated with osteoarthritis are presented as features that influence the lubricating properties of adjuvant candidates. Molecular dynamic simulation studies are presented, and the Rouse model is deployed, to rationalize low molecular weight hyaluronic acid behavior in an osteoarthritic environment of increased pH and phospholipid concentration. The results indicate that the hyaluronic acid radius of gyration time evolution is both pH- and phospholipid concentration-dependent. Specifically, dipalmitoylphosphatidylcholine induces hydrophobic interactions in the system, causing low molecular weight hyaluronic acid to shrink and at high concentration be absorbed into phospholipid vesicles. Low molecular weight hyaluronic acid appears to be insufficient for use as a tribological surgical adjuvant because an increased pH and phospholipid concentration induces decreased crosslinking that prevents the formation of supramolecular lubricating forms. Dipalmitoylphosphatidylcholine remains an adjuvant candidate for certain clinical situations. The need to reconcile osteoarthritic phenotypes is a prerequisite that should serve as a framework for future adjuvant design and subsequent tribological testing. Full article
(This article belongs to the Special Issue Hyaluronic Acid and its Derivatives for Biomedical Applications)
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Review

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Open AccessReview Pursuing Intracellular Pathogens with Hyaluronan. From a ‘Pro-Infection’ Polymer to a Biomaterial for ‘Trojan Horse’ Systems
Molecules 2018, 23(4), 939; https://doi.org/10.3390/molecules23040939
Received: 28 February 2018 / Revised: 12 April 2018 / Accepted: 13 April 2018 / Published: 18 April 2018
PDF Full-text (1740 KB) | HTML Full-text | XML Full-text
Abstract
Hyaluronan (HA) is among the most important bioactive polymers in mammals, playing a key role in a number of biological functions. In the last decades, it has been increasingly studied as a biomaterial for drug delivery systems, thanks to its physico-chemical features and
[...] Read more.
Hyaluronan (HA) is among the most important bioactive polymers in mammals, playing a key role in a number of biological functions. In the last decades, it has been increasingly studied as a biomaterial for drug delivery systems, thanks to its physico-chemical features and ability to target and enter certain cells. The most important receptor of HA is ‘Cluster of Differentiation 44’ (CD44), a cell surface glycoprotein over-expressed by a number of cancers and heavily involved in HA endocytosis. Moreover, CD44 is highly expressed by keratinocytes, activated macrophages and fibroblasts, all of which can act as ‘reservoirs’ for intracellular pathogens. Interestingly, both CD44 and HA appear to play a key role for the invasion and persistence of such microorganisms within the cells. As such, HA is increasingly recognised as a potential target for nano-carriers development, to pursuit and target intracellular pathogens, acting as a ‘Trojan Horse’. This review describes the biological relationship between HA, CD44 and the entry and survival of a number of pathogens within the cells and the subsequent development of HA-based nano-carriers for enhancing the intracellular activity of antimicrobials. Full article
(This article belongs to the Special Issue Hyaluronic Acid and its Derivatives for Biomedical Applications)
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