Special Issue "Host-Guest Chemistry"


A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: 15 July 2015

Special Issue Editor

Guest Editor
Dr. David B. Smithrud
Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA
Website: http://www.artsci.uc.edu/collegemain/faculty_staff/profile_details.aspx?ePID=MjczMjk%3D
E-Mail: david.smithrud@uc.edu
Interests: molecular recognition; cell transport; DNA binding agents; peptidomimetics; host-guest chemistry; catalysis; synthesis

Special Issue Information

Dear Colleagues,

In life, noncovalent complexation precludes the formation of covalent bonds and is a crucial step in signaling events. Chemists have spent many years constructing covalently linked hosts to replicate the noncovalent complexes observed in nature. The first generation of hosts formed strong noncovalent bonds with a guest through rigid pockets that matched a guest’s size. Although able to form tight complexes with some selectivity, these hosts did not achieve the very large association constants observed in nature and lacked function. The scope of this Special Issue highlights the newest approaches in constructing hosts to maximize guest association and perform function through dynamic motion.

Dr. David B. Smithrud
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).


  • host-guest
  • molecular recognition
  • sensors
  • biomimetics
  • protein mimetics

Published Papers (2 papers)

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p. 3354-3370
by  and
Molecules 2015, 20(2), 3354-3370; doi:10.3390/molecules20023354
Received: 27 December 2014 / Revised: 19 January 2015 / Accepted: 12 February 2015 / Published: 16 February 2015
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(This article belongs to the Special Issue Host-Guest Chemistry)
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p. 1775-1787
by ,  and
Molecules 2015, 20(2), 1775-1787; doi:10.3390/molecules20021775
Received: 9 December 2014 / Revised: 8 January 2015 / Accepted: 15 January 2015 / Published: 22 January 2015
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Last update: 7 January 2015

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