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Special Issue "Rotaxanes"

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A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (20 September 2013)

Special Issue Editor

Guest Editor
Dr. David B. Smithrud (Website)

Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA
Interests: molecular recognition; cell transport; DNA binding agents; peptidomimetics; host-guest chemistry; catalysis; synthesis

Special Issue Information

Dear Colleagues,

The wheel was one of the great inventions of mankind. Reinvention of the wheel in molecular chemistry gave birth to rotaxanes. The wheel is kinetically locked around a linear molecular axle with its slippage blocked by sterically hindering molecules attached to the ends of the axle. Controlling the spatial location of the wheel on the axle, as it naturally spins and slides, is the challenge for chemists who harness the power of the wheel to drive novel molecular machines. The scope of this Special Issue includes state of the art research harnessing the unique features of rotaxanes to construct a wide range of molecules from the small molecular devices such as sensors, switches, biomimetics, and transporters to the large supramolecular structures such as polyrotaxanes. Research papers and reviews dealing with the presented fields are welcome for the preparation of this Special Issue of Molecules.

Dr. David B. Smithrud
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).

Keywords

  • rotaxanes
  • polyrotaxanes
  • molecular sensors
  • molecular switches
  • molecular machines
  • delivery devices
  • host-guest chemistry
  • biomimetics

Published Papers (2 papers)

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Research

Open AccessArticle A Piston-Rotaxane with Two Potential Stripes: Force Transitions and Yield Stresses
Molecules 2013, 18(11), 13398-13409; doi:10.3390/molecules181113398
Received: 18 September 2013 / Revised: 18 October 2013 / Accepted: 22 October 2013 / Published: 30 October 2013
Cited by 5 | PDF Full-text (645 KB) | HTML Full-text | XML Full-text
Abstract
We examine a rod piston-rotaxane system, where the positions of several mobile rings on the axle are controlled by an external force acting on one of the rings. This allows us to access the translational entropy of the rings. For a simple [...] Read more.
We examine a rod piston-rotaxane system, where the positions of several mobile rings on the axle are controlled by an external force acting on one of the rings. This allows us to access the translational entropy of the rings. For a simple rotaxane molecule with an axle that has uniform ring-axle interactions along its length, the molecule behaves like a miniature piston filled with a one-dimensional ideal gas. We then examine the effect of two stripes on the axle, having different ring-axle interactions with the mobile rings, so that one section is of high energy (repulsive) for the rings and another section is of lower energy (or attractive). This kind of rotaxane can exhibit rapid changes in displacement or force, and in particular, this molecule can exhibit a yield stress in which the piston suddenly compresses under a small increase in the applied force. Full article
(This article belongs to the Special Issue Rotaxanes)
Open AccessArticle A pH-Sensitive Peptide-Containing Lasso Molecular Switch
Molecules 2013, 18(9), 11553-11575; doi:10.3390/molecules180911553
Received: 24 July 2013 / Revised: 9 September 2013 / Accepted: 11 September 2013 / Published: 17 September 2013
Cited by 9 | PDF Full-text (2753 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The synthesis of a peptide-containing lasso molecular switch by a self-entanglement strategy is described. The interlocked [1] rotaxane molecular machine consists of a benzometaphenylene[25]crown-8 (BMP25C8) macrocycle surrounding a molecular axle. This molecular axle contains a tripeptidic sequence and two molecular stations: a [...] Read more.
The synthesis of a peptide-containing lasso molecular switch by a self-entanglement strategy is described. The interlocked [1] rotaxane molecular machine consists of a benzometaphenylene[25]crown-8 (BMP25C8) macrocycle surrounding a molecular axle. This molecular axle contains a tripeptidic sequence and two molecular stations: a N-benzyltriazolium and a pH-sensitive anilinium station. The tripeptide is located between the macrocycle and the triazolium station, so that its conformation can be tailored depending on the shuttling of the macrocycle from one station to the other. At acidic pH, the macrocycle resides around the anilinium moiety, whereas it shuttles around the triazolium station after deprotonation. This molecular machinery thus forces the lasso to adopt a tightened or a loosened conformation. Full article
(This article belongs to the Special Issue Rotaxanes)
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