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Special Issue "Glycomimetics: Design, Synthesis and Therapeutic Applications"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: 30 January 2018

Special Issue Editor

Guest Editor
Prof. Dr. Philippe Compain

Laboratoire de Synthèse Organique et Molécules Bioactives (SYBIO), Université de Strasbourg et CNRS (UMR 7509), Ecole Européenne de Chimie, Polymères et Matériaux, 25 rue Becquerel, 67087 Strasbourg, France
Website | E-Mail
Interests: glycomimetics; multivalency; C-H functionalization; inhibitors; carbohydrate-processing enzymes; rare genetic diseases

Special Issue Information

Dear Colleagues,

Glycomimetics, as structurally altered analogues of sugars, offer the opportunity to emulate carbohydrate activities while circumventing their drawbacks as credible drugs. Structural modifications are performed not only to enhance target affinity and selectivity but also to improve drug-like properties, including oral bioavailability and in vivo stability. Beyond their biological interest, glycomimetics are an amazing playground for organic chemists. Creatively imagining new chemical structures that compete with one of the most important classes of biomolecules is a strong driving force. To paraphrase Marcellin Berthelot, organic chemists are indeed always eager to create their own objects of study. The high density of functional groups and asymmetric centers present in carbohydrate structures provide a rich source of inspiration. Beyond rational thinking, a kind of quest for molecular beauty via simplicity or symmetry is part of the design process. With regards to synthetic methodologies, the relative structural complexity of glycomimetics also provides a formidable testing ground for known reactions while permitting accidental discoveries in synthesis. In this Special Issue we intend to collect reviews, original research articles and short communications covering all current aspects of glycomimetic chemistry from innovative synthesis to potential therapeutic applications. Original research works on iminosugars, C-glycosides, square sugars or other sweet objects are therefore welcome, whether these glycomimetics were designed for the synthetic challenges they provide, for tackling fundamental questions in glycobiology, or for drug discovery.

Prof. Dr. Philippe Compain
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • glycomimetics
  • iminosugars
  • carbasugars
  • C-glycosides
  • thiosugars
  • multivalency
  • inhibitors
  • lectins
  • carbohydrate-processing enzymes
  • carbohydrate-mediated biological recognition

Published Papers

This special issue is now open for submission.
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