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Molecules 2018, 23(7), 1612; https://doi.org/10.3390/molecules23071612

Glycoside Mimics from Glycosylamines: Recent Progress

Institute of Organic and Analytical Chemistry, UMR 7311, University of Orleans and CNRS, Rue de Chartres, BP 6759, 45067 Orleans CEDEX 2, France
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Academic Editor: Philippe Compain
Received: 31 May 2018 / Revised: 26 June 2018 / Accepted: 28 June 2018 / Published: 2 July 2018
(This article belongs to the Special Issue Glycomimetics: Design, Synthesis and Therapeutic Applications)

Abstract

Glycosylamines are valuable sugar derivatives that have attracted much attention as synthetic intermediates en route to iminosugar-C-glycosyl compounds. Iminosugars are among the most important glycomimetics reported to date due to their powerful activities as inhibitors of a wide variety of glycosidases and glycosyltransferases, as well as for their use as pharmacological chaperones. As they provide ready access to these important glycoside mimics, we have reviewed the most significant glycosylamine-based methodologies developed to date, with a special emphasis on the literature reported after 2006. The groups of substrates covered include N-alkyl- and N-benzyl-glycosylamines, N-glycosylhydroxylamines, N-(alkoxycarbonyl)-, and N-tert-butanesulfinyl-glycosylamines. View Full-Text
Keywords: addition reactions; glycosylamines; iminosugar-C-glycosides; glycomimetics addition reactions; glycosylamines; iminosugar-C-glycosides; glycomimetics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Nicolas, C.; Martin, O.R. Glycoside Mimics from Glycosylamines: Recent Progress. Molecules 2018, 23, 1612.

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