Next Article in Journal
Comparative Metabolic Profiling of Green and Purple Pakchoi (Brassica Rapa Subsp. Chinensis)
Next Article in Special Issue
Glycomimetics: Design, Synthesis, and Therapeutic Applications
Previous Article in Journal
Immunomodulatory Action of Substituted 1,3,4-Thiadiazines on the Course of Myocardial Infarction
Previous Article in Special Issue
Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessFeature PaperReview
Molecules 2018, 23(7), 1612;

Glycoside Mimics from Glycosylamines: Recent Progress

Institute of Organic and Analytical Chemistry, UMR 7311, University of Orleans and CNRS, Rue de Chartres, BP 6759, 45067 Orleans CEDEX 2, France
Authors to whom correspondence should be addressed.
Academic Editor: Philippe Compain
Received: 31 May 2018 / Revised: 26 June 2018 / Accepted: 28 June 2018 / Published: 2 July 2018
(This article belongs to the Special Issue Glycomimetics: Design, Synthesis and Therapeutic Applications)


Glycosylamines are valuable sugar derivatives that have attracted much attention as synthetic intermediates en route to iminosugar-C-glycosyl compounds. Iminosugars are among the most important glycomimetics reported to date due to their powerful activities as inhibitors of a wide variety of glycosidases and glycosyltransferases, as well as for their use as pharmacological chaperones. As they provide ready access to these important glycoside mimics, we have reviewed the most significant glycosylamine-based methodologies developed to date, with a special emphasis on the literature reported after 2006. The groups of substrates covered include N-alkyl- and N-benzyl-glycosylamines, N-glycosylhydroxylamines, N-(alkoxycarbonyl)-, and N-tert-butanesulfinyl-glycosylamines. View Full-Text
Keywords: addition reactions; glycosylamines; iminosugar-C-glycosides; glycomimetics addition reactions; glycosylamines; iminosugar-C-glycosides; glycomimetics

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Nicolas, C.; Martin, O.R. Glycoside Mimics from Glycosylamines: Recent Progress. Molecules 2018, 23, 1612.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top