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Special Issue "Cyclic Peptides"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: 31 July 2018

Special Issue Editor

Guest Editor
Prof. Irene Izzo

Dipartimento di Chimica e Biologia "A. Zambelli", Università degli Studi,di Salerno, 84084 Fisciano (SA), Italy
Website | E-Mail
Interests: organic synthesis; asymmetric synthesis; marine natural products; peptido mimetics; peptides; cyclopeptoids

Special Issue Information

Dear Colleagues,

In recent decades, considerable efforts have been devoted to the isolation, characterization and synthesis of peptide macrocycles. Natural compounds and synthetic analogues have found applications that range from therapeutics to bionanomaterials. This is due to their functional and structural properties, good bioavailability and enzymatic stability, when compared to their linear counterparts. From a therapeutic point of view, though cyclopeptides show a wide range of biological activities (anti-cancer, cytotoxic, antimicrobial, anthelmintic, anti-HIV and anti-insecticidal), to date few mechanisms of action and molecular receptors are known. This explains the growing interest of academia and pharmaceutical companies for peptide-based macrocycles. Considering that isolation from natural sources is expensive and time consuming, synthetic organic chemistry plays a crucial role for the preparation of these macrocyclic targets. However, the presence of unusual amino acids, heterocyclic building blocks and ester linkages still represent a challenge for synthetic chemists (as much as the macrocyclization step itself). The present Special Issue is aimed at covering recent isolated cyclopeptides, new synthetic strategies, as well as novel applications in different areas of this intriguing class of compounds, being that the research on macrocycles is promising, exciting and still underexplored.

Prof. Irene  Izzo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • peptides
  • depsipeptides
  • macrocyclization
  • therapeutic agents
  • bionanomaterials

Published Papers

This special issue is now open for submission.
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