Special Issue "Cinnamic Acids Hybrids with Biological Interest"


A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: closed (31 October 2014)

Special Issue Editor

Guest Editor
Prof. D. Hadjipavlou-Litina
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Greece
Website: http://www.pharm.auth.gr/en/faculty/763
E-Mail: hadjipav@pharm.auth.gr
Interests: synthesis and pharmacochemical studies on anti inflammatory and antioxidant agents and inhibitors of enzymes implicated in the inflammation and coagulation processes and cancer, and the relationship between the structures and activities of various drug classes (Computational Chemistry in Drug Design).

Special Issue Information

Dear Colleagues,

Cinnamic acid derivatives from natural and synthetic sources have attracted much attention due to their significant biological activities (e.g., antioxidant, antitumor, antimicrobial activities). Recently, intensive research has been conducted on cinnamic acid hybrids, with the goal of creating new polyfunctional drugs based on them. Piplartin, an alkaloid and a trans-cinnamic acid derivative, which is isolated from Piper tuberculatum, has been shown to have antitumor and antiproliferative properties. A whole series of drugs has been created on the basis of cinnamic acid presenting antiallergic activity (e.g., Cinnarizine, Cinanserin, Tranilast).

Molecular hybridization consists of a molecular modification approach to obtain multifunctional ligands and drugs with better pharmacokinetic properties and the concomitant administration of two different agents. The design principle is aimed at combining the synergistic property of cinnamic acid with the sequestering activity of other biologically active chemical entities or molecules, so as to get compounds with better activities.

In this issue, we will present a number of several cinnamic hybrids, their syntheses, and biological evaluation, as well as reviews in related subjects.

Prof. D. Hadjipavlou-Litina
Guest Editor


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  • cinnamic acids
  • caffeic acid
  • inflammation
  • antioxidant activity
  • anticancer
  • conjugates
  • adducts
  • hybrids
  • multitarget

Published Papers (2 papers)

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p. 19292-19349
Molecules 2014, 19(12), 19292-19349; doi:10.3390/molecules191219292
Received: 20 October 2014; in revised form: 14 November 2014 / Accepted: 18 November 2014 / Published: 25 November 2014
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(This article belongs to the Special Issue Cinnamic Acids Hybrids with Biological Interest)
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p. 12940-12948
by , ,  and
Molecules 2014, 19(9), 12940-12948; doi:10.3390/molecules190912940
Received: 17 July 2014; in revised form: 11 August 2014 / Accepted: 18 August 2014 / Published: 25 August 2014
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Last update: 10 July 2014

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