Special Issue "Cinnamic Acids Hybrids with Biological Interest"
Deadline for manuscript submissions: closed (31 October 2014)
Prof. D. Hadjipavlou-Litina
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Greece
Interests: synthesis and pharmacochemical studies on anti inflammatory and antioxidant agents and inhibitors of enzymes implicated in the inflammation and coagulation processes and cancer, and the relationship between the structures and activities of various drug classes (Computational Chemistry in Drug Design).
Cinnamic acid derivatives from natural and synthetic sources have attracted much attention due to their significant biological activities (e.g., antioxidant, antitumor, antimicrobial activities). Recently, intensive research has been conducted on cinnamic acid hybrids, with the goal of creating new polyfunctional drugs based on them. Piplartin, an alkaloid and a trans-cinnamic acid derivative, which is isolated from Piper tuberculatum, has been shown to have antitumor and antiproliferative properties. A whole series of drugs has been created on the basis of cinnamic acid presenting antiallergic activity (e.g., Cinnarizine, Cinanserin, Tranilast).
Molecular hybridization consists of a molecular modification approach to obtain multifunctional ligands and drugs with better pharmacokinetic properties and the concomitant administration of two different agents. The design principle is aimed at combining the synergistic property of cinnamic acid with the sequestering activity of other biologically active chemical entities or molecules, so as to get compounds with better activities.
In this issue, we will present a number of several cinnamic hybrids, their syntheses, and biological evaluation, as well as reviews in related subjects.
Prof. D. Hadjipavlou-Litina
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
- cinnamic acids
- caffeic acid
- antioxidant activity