E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Special Issue "Frontier in Biocatalysis for Organic Synthesis"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: 20 July 2018

Special Issue Editors

Guest Editor
Dr. Frank Hollmann

Department of Biotechnology/Biocatalysis, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands
Website | E-Mail
Interests: redox biocatalysis; biocatalysis for organic synthesis; oxidation reactions; reduction reactions; oxyfunctionalization
Guest Editor
Dr. Selin Kara

Hamburg University of Technology, Institute of Technical Biocatalysis, Denickestr. 15, 21075, Hamburg, Germany
Website | E-Mail
Interests: biocatalytic cascade reactions; redox biocatalysis; biocatalysis in non-conventional media; enzyme immobilization; reaction engineering
Guest Editor
Dr. Caroline E. Paul

Laboratory of Organic Chemistry, Wageningen University & Research, Stippeneng 4, 6708WE Wageningen, The Netherlands
Website | E-Mail
Interests: biocatalysis; oxidoreductases; nicotinamide cofactors; synthetic coenzyme biomimetics; redox reactions

Special Issue Information

Dear Colleagues,

The importance of biocatalysis for organic synthesis is steadily growing. Already, enzymes are used by various chemical industries, but their potential is not yet fully tapped. Biocatalytic methods can give an alternative or complementary route in classical organic synthesis. An increasing number of biocatalytic processes, such as enzymatic cascades and hydrogen-borrowing systems, are being developed with new enzyme reactivity still being discovered. Spatial arrangements in multi-enzymatic systems via compartmentalization or co-immobilization of enzymes have been a useful tool to increase productivities.

In this Special Issue we aim to compile contributions from academic research and industrial application to showcase the potential, but also the current limitations of biocatalysis for organic synthesis.

Manuscripts describing new enzymatic reactions for organic synthesis, as well as manuscripts dealing with improved enzymatic processes based on engineered enzymes, optimized biocatalyst formulations, and/or engineered reaction setups are very welcome.

Dr. Frank Hollmann
Dr. Selin Kara
Dr. Caroline E. Paul
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biocatalysis for organic chemistry
  • biotransformations
  • (multi-step) enzymatic reactions
  • organic synthesis
  • spatial arrangements in enzymatic cascades
  • biocatalyst formulation for enzymatic synthesis
  • reaction engineering in biocatalytic systems

Published Papers (1 paper)

View options order results:
result details:
Displaying articles 1-1
Export citation of selected articles as:

Research

Open AccessArticle Lipase-Catalyzed Acidolysis of Egg-Yolk Phosphatidylcholine with Citronellic Acid. New Insight into Synthesis of Isoprenoid-Phospholipids
Molecules 2018, 23(2), 314; doi:10.3390/molecules23020314
Received: 16 January 2018 / Revised: 27 January 2018 / Accepted: 1 February 2018 / Published: 2 February 2018
PDF Full-text (1755 KB) | HTML Full-text | XML Full-text
Abstract
The development of a biotechnological method for the production of new biologically active phosphatidylcholine containing monoterpene citronellic acid (CA) was the aim of this work. Incorporation of citronellic acid (CA) into egg-yolk phosphatidylcholine (PC) in the lipase-catalyzed acidolysis process was studied. Isoprenoid acid
[...] Read more.
The development of a biotechnological method for the production of new biologically active phosphatidylcholine containing monoterpene citronellic acid (CA) was the aim of this work. Incorporation of citronellic acid (CA) into egg-yolk phosphatidylcholine (PC) in the lipase-catalyzed acidolysis process was studied. Isoprenoid acid CA was used as an acyl donor and five commercially available immobilized lipases were examined as biocatalysts. The effects of organic solvent, enzyme load, reaction time and molar ratio of substrates on the incorporation of citronellic acid (CA) into the phospholipids were evaluated. Modified phospholipid fraction enriched with CA in the sn-1 position (39% of incorporation) was obtained in high 33% yield using Novozym 435 as biocatalyst. In this study a biotechnological method for production of new phospholipid biopreparation enriched with citronellic acid, which can play an important role as a nutraceutical, was applied. Full article
(This article belongs to the Special Issue Frontier in Biocatalysis for Organic Synthesis)
Figures

Back to Top