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Molecules 2018, 23(2), 314; https://doi.org/10.3390/molecules23020314

Lipase-Catalyzed Acidolysis of Egg-Yolk Phosphatidylcholine with Citronellic Acid. New Insight into Synthesis of Isoprenoid-Phospholipids

Department of Chemistry, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50–375 Wrocław, Poland
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Received: 16 January 2018 / Revised: 27 January 2018 / Accepted: 1 February 2018 / Published: 2 February 2018
(This article belongs to the Special Issue Frontier in Biocatalysis for Organic Synthesis)
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Abstract

The development of a biotechnological method for the production of new biologically active phosphatidylcholine containing monoterpene citronellic acid (CA) was the aim of this work. Incorporation of citronellic acid (CA) into egg-yolk phosphatidylcholine (PC) in the lipase-catalyzed acidolysis process was studied. Isoprenoid acid CA was used as an acyl donor and five commercially available immobilized lipases were examined as biocatalysts. The effects of organic solvent, enzyme load, reaction time and molar ratio of substrates on the incorporation of citronellic acid (CA) into the phospholipids were evaluated. Modified phospholipid fraction enriched with CA in the sn-1 position (39% of incorporation) was obtained in high 33% yield using Novozym 435 as biocatalyst. In this study a biotechnological method for production of new phospholipid biopreparation enriched with citronellic acid, which can play an important role as a nutraceutical, was applied. View Full-Text
Keywords: acidolysis; egg-yolk phosphatidylcholine; citronellic acid; isoprenoids; lipase; anticancer activity acidolysis; egg-yolk phosphatidylcholine; citronellic acid; isoprenoids; lipase; anticancer activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Rychlicka, M.; Niezgoda, N.; Gliszczyńska, A. Lipase-Catalyzed Acidolysis of Egg-Yolk Phosphatidylcholine with Citronellic Acid. New Insight into Synthesis of Isoprenoid-Phospholipids. Molecules 2018, 23, 314.

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