Special Issue "Bioassay-Guided Isolation of Natural Products"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (28 February 2013)
Prof. Dr. Florence K. Gleason
Department of Plant Biology, University of Minnesota, 1445 Gortner Avenue, Saint Paul, MN 55108, USA
Phone: +1 612 625 4275
Interests: anti-bacterial compounds; cyanobacteria; herbicides; lactones; LC-MS; membrane disruptors photosystem II inhibitors; peptides
After suffering a twenty year decline, the field of natural products is currently assuming new prominence. Plants, animals, and microorganisms have always been a continual source of new and useful compounds. Modern analytical and genetic techniques have made it considerably easier to isolate and exploit these compounds for human uses such as antibiotics and pesticides. Bioassay-guided isolation is still the basic procedure for characterizing new natural products with defined biological activity. The most effective assays are rapid and specific. Microorganisms are usually the assay organism that best fits this description especially when attempting to isolate new antibiotics. The basic techniques of agar and broth assays can be enhanced by use of genetically modified test organisms to increase efficiency. Automated assays in microtiter plates allow the testing of large numbers of samples in a short time. Once a target compound has been tentatively identified, metabolomics techniques can be used to find the appropriate strain of producer and optimize production. Equipped with an array of sensitive and rapid assays and analytical methods, the natural product researcher is more prepared than ever to explore nature’s vast frontier of chemical wonders.
Prof. Dr. Florence K. Gleason
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
Article: Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B
Molecules 2014, 19(7), 9786-9797; doi:10.3390/molecules19079786
Received: 21 March 2014; in revised form: 24 June 2014 / Accepted: 2 July 2014 / Published: 8 July 2014| PDF Full-text (281 KB) | HTML Full-text | XML Full-text | Supplementary Files
Article: Bio-Activity and Dereplication-Based Discovery of Ophiobolins and Other Fungal Secondary Metabolites Targeting Leukemia Cells
Molecules 2013, 18(12), 14629-14650; doi:10.3390/molecules181214629
Received: 12 October 2013; in revised form: 15 November 2013 / Accepted: 21 November 2013 / Published: 26 November 2013| Cited by 2 | PDF Full-text (746 KB) | Supplementary Files
Article: Differential Growth Inhibitory Effects of Highly Oxygenated Guaianolides Isolated from the Middle Eastern Indigenous Plant Achillea falcata in HCT-116 Colorectal Cancer Cells
Molecules 2013, 18(7), 8275-8288; doi:10.3390/molecules18078275
Received: 21 May 2013; in revised form: 20 June 2013 / Accepted: 8 July 2013 / Published: 15 July 2013| PDF Full-text (297 KB)
Molecules 2013, 18(5), 5814-5857; doi:10.3390/molecules18055814
Received: 19 April 2013; in revised form: 24 April 2013 / Accepted: 7 May 2013 / Published: 17 May 2013| Cited by 3 | PDF Full-text (373 KB)
Article: The Use of Bio-Guided Fractionation to Explore the Use of Leftover Biomass in Dutch Flower Bulb Production as Allelochemicals against Weeds
Molecules 2013, 18(4), 4510-4525; doi:10.3390/molecules18044510
Received: 28 February 2013; in revised form: 28 March 2013 / Accepted: 12 April 2013 / Published: 17 April 2013| PDF Full-text (649 KB)
Article: Identification of Alternaria alternata Mycotoxins by LC-SPE-NMR and Their Cytotoxic Effects to Soybean (Glycine max) Cell Suspension Culture
Molecules 2013, 18(3), 2528-2538; doi:10.3390/molecules18032528
Received: 13 December 2012; in revised form: 29 January 2013 / Accepted: 16 February 2013 / Published: 26 February 2013| PDF Full-text (484 KB) | HTML Full-text | Supplementary Files
Last update: 4 February 2013