Special Issue "Bioassay-Guided Isolation of Natural Products"


A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (28 February 2013)

Special Issue Editor

Guest Editor
Prof. Dr. Florence K. Gleason
Department of Plant Biology, University of Minnesota, 1445 Gortner Avenue, Saint Paul, MN 55108, USA
Website: http://www.cbs.umn.edu/node/1855
E-Mail: iqa6016@umn.edu
Phone: +1 612 625 4275
Interests: anti-bacterial compounds; cyanobacteria; herbicides; lactones; LC-MS; membrane disruptors photosystem II inhibitors; peptides

Special Issue Information

Dear Colleagues,

After suffering a twenty year decline, the field of natural products is currently assuming new prominence. Plants, animals, and microorganisms have always been a continual source of new and useful compounds. Modern analytical and genetic techniques have made it considerably easier to isolate and exploit these compounds for human uses such as antibiotics and pesticides. Bioassay-guided isolation is still the basic procedure for characterizing new natural products with defined biological activity. The most effective assays are rapid and specific. Microorganisms are usually the assay organism that best fits this description especially when attempting to isolate new antibiotics. The basic techniques of agar and broth assays can be enhanced by use of genetically modified test organisms to increase efficiency. Automated assays in microtiter plates allow the testing of large numbers of samples in a short time. Once a target compound has been tentatively identified, metabolomics techniques can be used to find the appropriate strain of producer and optimize production. Equipped with an array of sensitive and rapid assays and analytical methods, the natural product researcher is more prepared than ever to explore nature’s vast frontier of chemical wonders.

Prof. Dr. Florence K. Gleason
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).

Published Papers (6 papers)

by , , , , ,  and
Molecules 2014, 19(7), 9786-9797; doi:10.3390/molecules19079786
Received: 21 March 2014; in revised form: 24 June 2014 / Accepted: 2 July 2014 / Published: 8 July 2014
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abstract graphic

by , , , , , ,  and
Molecules 2013, 18(12), 14629-14650; doi:10.3390/molecules181214629
Received: 12 October 2013; in revised form: 15 November 2013 / Accepted: 21 November 2013 / Published: 26 November 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (746 KB) | Supplementary Files

by , , , ,  and
Molecules 2013, 18(7), 8275-8288; doi:10.3390/molecules18078275
Received: 21 May 2013; in revised form: 20 June 2013 / Accepted: 8 July 2013 / Published: 15 July 2013
Show/Hide Abstract | PDF Full-text (297 KB)

by , , ,  and
Molecules 2013, 18(5), 5814-5857; doi:10.3390/molecules18055814
Received: 19 April 2013; in revised form: 24 April 2013 / Accepted: 7 May 2013 / Published: 17 May 2013
Show/Hide Abstract | Cited by 3 | PDF Full-text (373 KB)
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by , , ,  and
Molecules 2013, 18(4), 4510-4525; doi:10.3390/molecules18044510
Received: 28 February 2013; in revised form: 28 March 2013 / Accepted: 12 April 2013 / Published: 17 April 2013
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abstract graphic

by , , ,  and
Molecules 2013, 18(3), 2528-2538; doi:10.3390/molecules18032528
Received: 13 December 2012; in revised form: 29 January 2013 / Accepted: 16 February 2013 / Published: 26 February 2013
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Last update: 4 February 2013

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