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Molecules 2014, 19(7), 9786-9797; doi:10.3390/molecules19079786
Article

Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B

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Received: 21 March 2014; in revised form: 24 June 2014 / Accepted: 2 July 2014 / Published: 8 July 2014
(This article belongs to the Special Issue Bioassay-Guided Isolation of Natural Products)
View Full-Text   |   Download PDF [281 KB, updated 9 July 2014; original version uploaded 8 July 2014]   |   Browse Figures
Abstract: Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spectroscopic analysis, supported by high resolution mass spectrometry (HRMS). Compounds 2 and 3 displayed cytotoxic activity towards chronic lymphocytic leukemia cells in vitro, with 3 being the most active.
Keywords: cytochalasins; apergilli; Apsergillus sclerotioniger; chronic lymphocytic leukemia cytochalasins; apergilli; Apsergillus sclerotioniger; chronic lymphocytic leukemia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Petersen, L.M.; Bladt, T.T.; Dürr, C.; Seiffert, M.; Frisvad, J.C.; Gotfredsen, C.H.; Larsen, T.O. Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B. Molecules 2014, 19, 9786-9797.

AMA Style

Petersen LM, Bladt TT, Dürr C, Seiffert M, Frisvad JC, Gotfredsen CH, Larsen TO. Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B. Molecules. 2014; 19(7):9786-9797.

Chicago/Turabian Style

Petersen, Lene M.; Bladt, Tanja T.; Dürr, Claudia; Seiffert, Martina; Frisvad, Jens C.; Gotfredsen, Charlotte H.; Larsen, Thomas O. 2014. "Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B." Molecules 19, no. 7: 9786-9797.


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