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Molecules 2014, 19(7), 9786-9797; https://doi.org/10.3390/molecules19079786

Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B

1
Department of Systems Biology, Technical University of Denmark, Søltofts Plads B221, DK-2800 Kgs. Lyngby, Denmark
2
German Cancer Research Center, Molecular Genetics, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
3
Department of Chemistry, Technical University of Denmark, Kemitorvet, B201, DK-2800 Kgs. Lyngby, Denmark
*
Author to whom correspondence should be addressed.
Received: 21 March 2014 / Revised: 24 June 2014 / Accepted: 2 July 2014 / Published: 8 July 2014
(This article belongs to the Special Issue Bioassay-Guided Isolation of Natural Products)
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Abstract

Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spectroscopic analysis, supported by high resolution mass spectrometry (HRMS). Compounds 2 and 3 displayed cytotoxic activity towards chronic lymphocytic leukemia cells in vitro, with 3 being the most active. View Full-Text
Keywords: cytochalasins; apergilli; Apsergillus sclerotioniger; chronic lymphocytic leukemia cytochalasins; apergilli; Apsergillus sclerotioniger; chronic lymphocytic leukemia
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Petersen, L.M.; Bladt, T.T.; Dürr, C.; Seiffert, M.; Frisvad, J.C.; Gotfredsen, C.H.; Larsen, T.O. Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B. Molecules 2014, 19, 9786-9797.

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