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Molecules 2014, 19(7), 9786-9797; doi:10.3390/molecules19079786
Article

Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B

1
,
1
,
2
,
2
,
1
,
3
 and
1,*
1 Department of Systems Biology, Technical University of Denmark, Søltofts Plads B221, DK-2800 Kgs. Lyngby, Denmark 2 German Cancer Research Center, Molecular Genetics, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany 3 Department of Chemistry, Technical University of Denmark, Kemitorvet, B201, DK-2800 Kgs. Lyngby, Denmark
* Author to whom correspondence should be addressed.
Received: 21 March 2014 / Revised: 24 June 2014 / Accepted: 2 July 2014 / Published: 8 July 2014
(This article belongs to the Special Issue Bioassay-Guided Isolation of Natural Products)
View Full-Text   |   Download PDF [281 KB, 9 July 2014; original version 8 July 2014]   |  

Abstract

Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spectroscopic analysis, supported by high resolution mass spectrometry (HRMS). Compounds 2 and 3 displayed cytotoxic activity towards chronic lymphocytic leukemia cells in vitro, with 3 being the most active.
Keywords: cytochalasins; apergilli; Apsergillus sclerotioniger; chronic lymphocytic leukemia cytochalasins; apergilli; Apsergillus sclerotioniger; chronic lymphocytic leukemia
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Petersen, L.M.; Bladt, T.T.; Dürr, C.; Seiffert, M.; Frisvad, J.C.; Gotfredsen, C.H.; Larsen, T.O. Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B. Molecules 2014, 19, 9786-9797.

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