Next Article in Journal
The Hydractinia echinata Test-System. III: Structure-Toxicity Relationship Study of Some Azo-, Azo-Anilide, and Diazonium Salt Derivatives
Previous Article in Journal
Vasorelaxation Induced by a New Naphthoquinone-Oxime is Mediated by NO-sGC-cGMP Pathway
Previous Article in Special Issue
Bio-Activity and Dereplication-Based Discovery of Ophiobolins and Other Fungal Secondary Metabolites Targeting Leukemia Cells
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(7), 9786-9797; doi:10.3390/molecules19079786

Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B

1
Department of Systems Biology, Technical University of Denmark, Søltofts Plads B221, DK-2800 Kgs. Lyngby, Denmark
2
German Cancer Research Center, Molecular Genetics, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
3
Department of Chemistry, Technical University of Denmark, Kemitorvet, B201, DK-2800 Kgs. Lyngby, Denmark
*
Author to whom correspondence should be addressed.
Received: 21 March 2014 / Revised: 24 June 2014 / Accepted: 2 July 2014 / Published: 8 July 2014
(This article belongs to the Special Issue Bioassay-Guided Isolation of Natural Products)
View Full-Text   |   Download PDF [281 KB, 9 July 2014; original version 8 July 2014]   |  

Abstract

Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spectroscopic analysis, supported by high resolution mass spectrometry (HRMS). Compounds 2 and 3 displayed cytotoxic activity towards chronic lymphocytic leukemia cells in vitro, with 3 being the most active.
Keywords: cytochalasins; apergilli; Apsergillus sclerotioniger; chronic lymphocytic leukemia cytochalasins; apergilli; Apsergillus sclerotioniger; chronic lymphocytic leukemia
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Petersen, L.M.; Bladt, T.T.; Dürr, C.; Seiffert, M.; Frisvad, J.C.; Gotfredsen, C.H.; Larsen, T.O. Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B. Molecules 2014, 19, 9786-9797.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top