Special Issue "PET Chemistry in Molecular Imaging"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (31 March 2013)
Dr. Paul Schaffer
Head, Nuclear Medicine, TRIUMF, 4004 Wesbrook Mall, Vancouver, BC, Canada V6T 2A3
Phone: +1 604 222 7696
Fax: +1 604 222 1074
Interests: radiochemistry; radiopharmaceutical development; molecular imaging; positron emission tomography, radioisotope production and applications
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
Molecules 2013, 18(5), 5005-5031; doi:10.3390/molecules18055005
Received: 25 March 2013; in revised form: 13 April 2013 / Accepted: 19 April 2013 / Published: 29 April 2013| Download PDF Full-text (521 KB)
Article: Chelator-Accelerated One-Pot ‘Click’ Labeling of Small Molecule Tracers with 2-[18F]Fluoroethyl Azide
Molecules 2013, 18(5), 5335-5347; doi:10.3390/molecules18055335
Received: 8 April 2013; in revised form: 16 April 2013 / Accepted: 3 May 2013 / Published: 10 May 2013| Download PDF Full-text (370 KB)
Review: Radiolabeled COX-2 Inhibitors for Non-Invasive Visualization of COX-2 Expression and Activity — A Critical Update
Molecules 2013, 18(6), 6311-6355; doi:10.3390/molecules18066311
Received: 29 March 2013; in revised form: 16 May 2013 / Accepted: 24 May 2013 / Published: 29 May 2013| Download PDF Full-text (654 KB)
Review: 89Zr, a Radiometal Nuclide with High Potential for Molecular Imaging with PET: Chemistry, Applications and Remaining Challenges
Molecules 2013, 18(6), 6469-6490; doi:10.3390/molecules18066469
Received: 26 March 2013; in revised form: 24 May 2013 / Accepted: 29 May 2013 / Published: 3 June 2013| Download PDF Full-text (406 KB)
Article: Synthesis and Radiolabelling of DOTA-Linked Glutamine Analogues with 67,68Ga as Markers for Increased Glutamine Metabolism in Tumour Cells
Molecules 2013, 18(6), 7160-7178; doi:10.3390/molecules18067160
Received: 1 April 2013; in revised form: 10 May 2013 / Accepted: 8 June 2013 / Published: 19 June 2013| Download PDF Full-text (511 KB)
Article: A Fully Automated Radiosynthesis of [18F]Fluoroethyl-Diprenorphine on a Single Module by Use of SPE Cartridges for Preparation of High Quality 2-[18F]Fluoroethyl Tosylate
Molecules 2013, 18(6), 7271-7278; doi:10.3390/molecules18067271
Received: 1 May 2013; in revised form: 16 May 2013 / Accepted: 4 June 2013 / Published: 20 June 2013| Download PDF Full-text (300 KB)
Molecules 2013, 18(7), 7930-7956; doi:10.3390/molecules18077930
Received: 3 June 2013; in revised form: 21 June 2013 / Accepted: 3 July 2013 / Published: 5 July 2013| Download PDF Full-text (583 KB)
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Microfluidics: A Groundbreaking Technology for PET Tracer Production?
Authors: C. Rensch 1, A. Jackson 2, S. Lindner 3, R. Horvath-Klein 1, V. Samper 1, S. Riese 2, C. Wängler 3,4 and B. Wängler 5
Affiliations: 1 GE Global Research, Germany
2 GE Healthcare, UK / Germany
3 Klinik und Poliklinik für Nuklearmedizin, Klinikum der Universität München, Germany
4 Biomedizinische Chemie, IKRN, Medizinische Fakultät Mannheim der Universitär Heidelberg, Germany
5 Molekulare Bildgebung und Radiochemie, IKRN, Medizinische Fakultät Mannheim der Universitaet Heidelberg, Germany
Abstract: Microfluidics applied to Positron Emission Tomography (PET) tracer synthesis has gained increasing interest within the last decade. Among these, especially capillary-based microfluidic systems have entered the commercial space. The main advantages of microfluidics for PET tracer synthesis such as reduced reaction time, increased synthesis yield, highly efficient reaction optimization, reduced consumption of expensive reagents and a perspective towards a reduced system footprint have been successfully demonstrated recently. Furthermore, the processing of radioactivity levels required for routine production, employment of microfluidic produced PET tracer doses to preclinical and clinical imaging as well as feasibility studies on autoradiolytic decomposition at a microfluidic scale gave promising results. Thus, microfluidics has shown to result in a highly favorable technical advantage. Howver, the number of microfluidic synthesizers utilized for commercial routine production of PET tracers is yet very limited which is due to remaining challenges depending on system architecture, such as reproducibility, reliability, compliance to good manufacturing practice (GMP), cost of goods per synthesis and convenience of use that remain to be addressed. Hence, the question which seems to remain is about the engineering vehicle that enables microfluidic technology for routine PET tracer production. This study reviews the state of the art in microfluidic PET tracer synthesis, it highlights critical design aspects, strengths, weaknesses and presents the big picture of the diverse PET market space which is thought to have a significant impact on research, development and engineering of microfluidic devices in this field. Furthermore, aspects such as cost per dose, back-to-back, single dose, cyclotron to quality control integration, small and large batch tracer production as well as centralized versus de-centralized market distribution models are addressed.
Last update: 12 March 2013