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Molecules 2013, 18(6), 7271-7278; doi:10.3390/molecules18067271
Article

A Fully Automated Radiosynthesis of [18F]Fluoroethyl-Diprenorphine on a Single Module by Use of SPE Cartridges for Preparation of High Quality 2-[18F]Fluoroethyl Tosylate

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Received: 1 May 2013 / Revised: 16 May 2013 / Accepted: 4 June 2013 / Published: 20 June 2013
(This article belongs to the Special Issue PET Chemistry in Molecular Imaging)
Download PDF [300 KB, 18 June 2014; original version 18 June 2014]

Abstract

We have developed a new method for automated production of 2-[18F]fluoroethyl tosylate ([18F]FETos) that enables 18F-alkylation to provide PET tracers with high chemical purity. The method is based on the removal of excess ethylene glycol bistosylate precursor by precipitation and subsequent filtration and purification of the filtrate by means of solid phase extraction cartridges (SPE). The method is integrated to a single synthesis module and thereby provides the advantage over previous methods of not requiring HPLC purification, as demonstrated by the full radiosynthesis of the potent opioid receptor PET tracer [18F]fluoroethyldiprenorphine.
Keywords: 2-[18F]fluoroethyl tosylate; 18F-fluoroalkylation; PET; opioid receptors; automation; solid phase extraction 2-[18F]fluoroethyl tosylate; 18F-fluoroalkylation; PET; opioid receptors; automation; solid phase extraction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Schoultz, B.W.; Reed, B.J.; Marton, J.; Willoch, F.; Henriksen, G. A Fully Automated Radiosynthesis of [18F]Fluoroethyl-Diprenorphine on a Single Module by Use of SPE Cartridges for Preparation of High Quality 2-[18F]Fluoroethyl Tosylate. Molecules 2013, 18, 7271-7278.

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