Special Issue "Radioisotope Production and Applications"


A special issue of Applied Sciences (ISSN 2076-3417).

Deadline for manuscript submissions: closed (31 July 2013)

Special Issue Editor

Guest Editor
Dr. Paul Schaffer
Head, Nuclear Medicine, TRIUMF, 4004 Wesbrook Mall, Vancouver, BC, Canada V6T 2A3
Website: http://www.triumf.ca/nrcan-nisp/triumf-team
E-Mail: pschaffer@triumf.ca
Phone: +1 604 222 7696
Fax: +1 604 222 1074
Interests: radiochemistry; radiopharmaceutical development; molecular imaging; positron emission tomography, radioisotope production and applications

Special Issue Information

Dear Colleagues,

Molecular imaging has enabled health professionals and basic researchers to probe the function of living systems at the molecular level, enabling non-invasive studies into functional changes that take place during the onset and progression of disease, well before anatomical changes occur. Understanding the molecular progression of disease is changing the way it is diagnosed, staged and treated and will ultimately enable a paradigm of personalized healthcare.

Between 20 and 40 million single photon- and positron emission tomography (SPECT and PET) scans are performed each year around the world in patients suffering from heart ailments, cancer and neurological diseases like Parkinson’s and Alzheimer’s. With new biological questions about these diseases (and others) continuously emerging, novel ways of producing medical isotopes, converting them into radiopharmaceuticals and demonstrating in vivo efficacy are of paramount importance. Such an effort requires amalgamation of basic and applied research across the disciplines of physics, chemistry and biology—all of which are geared toward the development of better imaging protocols or contrast-enhancing biological probes.

The widespread acceptance of new and promising radioisotopes and radiopharmaceuticals is typically challenged by their availability and accessibility. Despite the advances in availability of medical cyclotrons in the hospital setting, new isotope production, isolation and application remains a difficult task for most institutions. Couple this with the anticipated shutdown of the world’s major 99mTc production reactor and accelerator-based production facilities will face an increasing responsibility to meet isotope demands of the healthcare community.

The need to install novel infrastructure and/or purchase isotope generators necessitates a substantial technical and financial commitment that may be difficult to justify, especially if preliminary biological studies are warranted to establish proof of feasibility for the isotopes in question. These obstacles likely inhibit the development of novel tracers that may possess a better match between the physical half-life of a promising new radioisotope and the pharmacokinetic profile of the vector to which it is attached.

This special issue of Applied Sciences, titled “Radioisotope Production and Application” aims to cover recent advances in the development of new and promising production methods for metallic and non-metallic medical isotopes, as well as new radiochemical techniques for radiopharmaceutical production and their use in novel applications. Reviews are also welcome.

Dr. Paul Schaffer
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. Article Processing Charge (APC) will be waived for well-prepared manuscripts submitted before the end of 2012, Article Processing Charge will be 300 CHF from 2013. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • cyclotron
  • cyclotron target design, operation
  • isotope production, isolation
  • medical radioisotopes
  • radiometals
  • radiopharmaceutical chemistry
  • radiopharmaceuticals
  • positron emission tomography (PET)
  • single photon emission computed tomography (SPECT)
  • molecular imaging

Published Papers (5 papers)

Appl. Sci. 2014, 4(2), 265-281; doi:10.3390/app4020265
Received: 10 November 2013; in revised form: 27 January 2014 / Accepted: 25 February 2014 / Published: 16 May 2014
Show/Hide Abstract | Cited by 1 | PDF Full-text (4706 KB) | HTML Full-text | XML Full-text

Appl. Sci. 2014, 4(1), 66-78; doi:10.3390/app4010066
Received: 30 April 2013; in revised form: 7 February 2014 / Accepted: 27 February 2014 / Published: 17 March 2014
Show/Hide Abstract | PDF Full-text (535 KB) | HTML Full-text | XML Full-text
abstract graphic

Appl. Sci. 2013, 3(4), 675-683; doi:10.3390/app3040675
Received: 26 July 2013; in revised form: 8 October 2013 / Accepted: 21 October 2013 / Published: 28 October 2013
Show/Hide Abstract | PDF Full-text (1145 KB) | HTML Full-text | XML Full-text

Appl. Sci. 2013, 3(3), 636-655; doi:10.3390/app3030636
Received: 24 July 2013; in revised form: 29 August 2013 / Accepted: 9 September 2013 / Published: 18 September 2013
Show/Hide Abstract | PDF Full-text (691 KB) | HTML Full-text | Supplementary Files
abstract graphic

Appl. Sci. 2013, 3(3), 593-613; doi:10.3390/app3030593
Received: 9 May 2013; in revised form: 12 June 2013 / Accepted: 24 June 2013 / Published: 12 July 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (1387 KB) | HTML Full-text | XML Full-text

Last update: 28 August 2013

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