Special Issue "Nucleoside Modifications"


A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Molecular Diversity".

Deadline for manuscript submissions: 28 February 2015

Special Issue Editors

Guest Editor
Professor Mahesh K. Lakshman
Department of Chemistry, The City College and The City University of New York, New York, NY 10031, USA
Website: http://www.ccny.cuny.edu/profiles/Mahesh-Lakshman.cfm
E-Mail: lakshman@sci.ccny.cuny.edu
Interests: Nucleoside modification via metal-catalyzed and uncatalyzed processes, synthesis of novel nucleoside structures, chemical carcinogenesis, site-specific DNA modification, synthesis of polycyclic aromatic hydrocarbons and their metabolites, aryne chemistry, and generally applicable synthetic methodology

Guest Editor
Professor Fumi Nagatsugi
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai-shi, Japan
Website: http://www.sci.tohoku.ac.jp/amc/prof_nagatsugi_t.html
E-Mail: nagatugi@tagen.tohoku.ac.jp
Interests: Oligonucleotides, artificial molecules for binding to DNA and RNA, selective chemical reactions to DNA and RNA

Special Issue Information

Dear Colleagues,

Nucleosides are the fundamental components of genetic material, and are present in all living organisms, and in viruses. By virtue of their ubiquity, they are highly important biomolecules. Nucleosides consist of a heterocyclic aglycone and a sugar unit. For several decades, the natural nucleoside structures have inspired the development of chemical and biochemical modifications, leading to new nucleoside-like entities via aglycone, as well as saccharide, modifications. As a result, modified nucleosides and nucleoside analogues have wide spread utilities in biochemistry, biology, as pharmaceutical agents, and as biological probes. There is a constant need for access to novel nucleoside analogues for a plethora of applications, prompting the development of new methodologies.  This Special Issue aims to provide a forum for the dissemination of the latest information on new chemical methods for access to modified nucleosides, nucleoside analogues, and applications of these new molecules.

Professor Mahesh K. Lakshman
Professor Fumi Nagatsugi
Guest Editors


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).

Published Papers (3 papers)

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Displaying article 1-3
p. 1078-1087
by ,  and
Molecules 2015, 20(1), 1078-1087; doi:10.3390/molecules20011078
Received: 9 December 2014 / Accepted: 7 January 2015 / Published: 9 January 2015
Show/Hide Abstract | PDF Full-text (887 KB) | Supplementary Files
(This article belongs to the Special Issue Nucleoside Modifications)
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p. 21200-21214
by , , , ,  and
Molecules 2014, 19(12), 21200-21214; doi:10.3390/molecules191221200
Received: 23 October 2014 / Revised: 8 December 2014 / Accepted: 9 December 2014 / Published: 16 December 2014
Show/Hide Abstract | PDF Full-text (794 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Nucleoside Modifications)
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p. 16976-16986
by ,  and
Molecules 2014, 19(10), 16976-16986; doi:10.3390/molecules191016976
Received: 16 September 2014 / Revised: 8 October 2014 / Accepted: 17 October 2014 / Published: 22 October 2014
Show/Hide Abstract | PDF Full-text (449 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Nucleoside Modifications)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Palladium-Catalyzed Functionalization Of Unprotected Nucleosides in Aqueous Media

Dr. Kevin Shaughnessy, Ph.D
Professor and Chair
2004 (chair's office)/2072 Shelby Hall
Department of Chemistry
The University of Alabama
Box 870336 (mailing), 250 Hackberry Ln (shipments)
Tuscaloosa, AL 35487-0336 (35401 for shipments)
ph: (205) 348-4435
Fax: (205) 348-9104
E-Mail: kshaughn@ua.edu
Website: http://bama.ua.edu/~kshaughn

Stanislaw F. Wnuk, Ph.D.
: Direct Arylation of Purine and Pyrimidine Nucleosides by C-H Bond Activation

Stanislaw F. Wnuk, Ph.D.
Professor, Department of Chemistry and Biochemistry,
Interim Chair, Department of Environmental & Occupational Health
Florida International University
Miami, FL 33199
Tel: (305) 348-6195
Website: http://faculty.fiu.edu/~wnuk

Prof. Dr. Yuichi Yoshimura
Title: Synthesis of Isonucleoside Built on a 2,6-dioxobicyclo[3.2.0]heptane Skeleton

Prof. Dr. Yuichi Yoshimura
Pharmaceutical Sciences, Tohoku Pharmaceutical University
E-Mail: yoshimura@tohoku-pharm.ac.jp

Prof. Dr. Fumi Nagatsugi
Title: Synthesis of Peptide Nucleic Acids Containing the Crosslinking Agent and Evaluation of the Reactivity

Prof. Dr. Fumi Nagatsugi
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
E-Mail: nagatugi@tagen.tohoku.ac.jp
Website: http://www.sci.tohoku.ac.jp/amc/prof_nagatsugi_t.html

Professor Dr. Takeshi Wada
Title: Enhancement of Affinity of 2′-O-Me-oligonucleotides for Complementary RNA by Incorporating a Stereoregulated Boranophosphate Backbone

Professor Dr. Takeshi Wada
Pharmaceutical Sciences, Tokyo University of Science
E-Mail: twada@rs.tus.ac.jp

Prof. Dr. Masad Dhama
Title: Synthetic Pathways towards Analogues of Nucleosides Comprising Heterocyclic Six- and Seven-Membered Ring Sugars

Prof. Dr. Masad Dhama
Department of Chemistry, McGill University
E-Mail: masad.damha@mcgill.ca

Tethering in RNA: An RNA-Binding Fragment Discovery Tool

Peter A. Beal, PhD
Professor, Department of Chemistry
University of California, Davis
Davis, CA 95616, USA
E-Mail: pabeal@ucdavis.edu
Website: http://chemgroups.ucdavis.edu/~beal/

Title: "Carboxylated Acyclonucleosides as Ribonuclease A Inhibitors"

Tanmaya Pathak, PhD
Tanmaya Pathak, PhD
Professor and Head
Department of Chemistry, Indian Institute of Technology
E-Mail: tpathak@chem.iitkgp.ernet.in
Website: http://www.chem.iitkgp.ernet.in/faculty/PT/index.php

Swagata Dasgupta, PhD
Swagata Dasgupta, PhD
Department of Chemistry, Indian Institute of Technology Kharagpur
E-Mail: swagata@chem.iitkgp.ernet.in
Website: http://www.chem.iitkgp.ernet.in/faculty/SDG/index.php

Title: Non-nucleosidic analogues of polyaminonucleosides and their influence on thermodynamic properties of derived oligonucleotides
Prof. Dr. Wojciech T. Markiewicz
Institute of Bioorganic Chemistry
Polish Academy of Sciences
Noskowskiego 12/14,
61-704 Poznań, Poland
T +48 61 8528503
M +48 601 793 527


Last update: 15 January 2015

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