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Molecules 2015, 20(3), 4708-4719; doi:10.3390/molecules20034708

Synthesis of Peptide Nucleic Acids Containing a Crosslinking Agent and Evaluation of Their Reactivities

Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai-shi, Miyagi 980-8577, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Mahesh K. Lakshman
Received: 26 January 2015 / Revised: 3 March 2015 / Accepted: 9 March 2015 / Published: 13 March 2015
(This article belongs to the Special Issue Nucleoside Modifications)
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Abstract

Peptide nucleic acids (PNAs) are structural mimics of nucleic acids that form stable hybrids with DNA and RNA. In addition, PNAs can invade double-stranded DNA. Due to these characteristics, PNAs are widely used as biochemical tools, for example, in antisense/antigene therapy. Interstrand crosslink formation in nucleic acids is one of the strategies for preparing a stable duplex by covalent bond formation. In this study, we have synthesized PNAs incorporating 4-amino-6-oxo-2-vinylpyrimidine (AOVP) as a crosslinking agent and evaluated their reactivities for targeting DNA and RNA. View Full-Text
Keywords: peptide nucleic acid (PNA); crosslink; antisense; invasion peptide nucleic acid (PNA); crosslink; antisense; invasion
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Akisawa, T.; Ishizawa, Y.; Nagatsugi, F. Synthesis of Peptide Nucleic Acids Containing a Crosslinking Agent and Evaluation of Their Reactivities. Molecules 2015, 20, 4708-4719.

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