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Special Issue "Chitosan-Based Nanomaterials for Biomedical Applications"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 28 February 2019

Special Issue Editor

Guest Editor
Prof. Dr. Jyh-Ping Chen

Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan, Taiwan
Website | E-Mail
Interests: biomaterials; bionanotechnoogy; tissue engineering; drug delivery; nanomedicine; bionanocomposites

Special Issue Information

Dear Colleagues,

Being the second most abundant natural polymer on Earth, chitosan possesses many unique chemical, structural and biological properties that make it attractive for numerous biomedical applications. Chitosan can be easily fabricated into different nanomaterials or nanocomposites, such as nanofibers, nanoparticles, gels, micelles and liposomes, to suit different needs. In addition, numerous approaches developed for chitosan have also overcome limitations in biomedical fields by using chitosan derivatives, composites or nanocomposites. Although numerous papers have discussed the application of chitosan nanomaterials in biomedical fields, they are found dispersed in different scientific journals. Consequently, this Special Issue aims to provide a broad coverage of recent research progress or up-to-date reviews addressing various aspects in this field. With this Special Issue, we aim to provide the readers with the opportunity to learn about different facets of biomedical research using chitosan-based nanomaterials. For the authors, this Special Issue will provide a unique opportunity to make their research results more visible to the scientific community. This Special Issue is seeking contributions from researchers to discuss all application aspects of chitosan nanomaterials in tissue engineering, regenerative medicine, drug delivery, wound healing and diagnostics. Critical reviews by experts in these fields are also welcomed.

Prof. Jyh-Ping Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Chitosan
  • Tissue Engineering
  • Regenerative Medicine
  • Drug Delivery
  • Wound Healing
  • Diagnostics
  • Nanomaterials

Published Papers (1 paper)

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Open AccessArticle Chitosan Nanoparticles with Encapsulated Natural and UF-Purified Annatto and Saffron for the Preparation of UV Protective Cosmetic Emulsions
Molecules 2018, 23(9), 2107; https://doi.org/10.3390/molecules23092107
Received: 20 July 2018 / Revised: 17 August 2018 / Accepted: 20 August 2018 / Published: 22 August 2018
PDF Full-text (5136 KB) | HTML Full-text | XML Full-text
The aim of the present work is to evaluate the preparation of sunscreen emulsions based on chitosan (CS) nanoparticles with annatto, ultrafiltrated (UF) annatto, saffron, and ultrafiltrated saffron. Ionic gelation was used for the preparation of chitosan nanoparticles, while their morphological characteristics and
[...] Read more.
The aim of the present work is to evaluate the preparation of sunscreen emulsions based on chitosan (CS) nanoparticles with annatto, ultrafiltrated (UF) annatto, saffron, and ultrafiltrated saffron. Ionic gelation was used for the preparation of chitosan nanoparticles, while their morphological characteristics and physicochemical properties were evaluated via Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) analysis, scanning electron microscopy (SEM), and dynamic light scattering (DLS). Results showed that the prepared nanoparticles ranged from ~150 to ~500 nm and had a spherical or irregular shape. In the case of annatto and UF annatto, due to the formation of H-bonds, the sunscreen agents were amorphously dispersed within CS nanoparticles, while in the case of saffron and UF saffron, crystalline dispersion was observed. All encapsulated materials had good thermal stability as well as color stability. In a further step, sunscreen emulsions were prepared based on the formed CS-sunscreen nanoparticles and evaluated for their stability in terms of pH and viscosity, along with their ultraviolet (UV) radiation protection ability in terms of sun protection factor (SPF). All prepared emulsions showed low cytotoxicity and good storage stability for up to 90 days, while minimum sunscreen protection was observed with SPF values varying from 2.15 to 4.85. Full article
(This article belongs to the Special Issue Chitosan-Based Nanomaterials for Biomedical Applications)

Graphical abstract

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type: Review
Title: Chitosan-Based Nanomaterials for Drug Delivery
Author: Chao Cai
Affiliation: Key Lab of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Drug Building A303, No.5 Yushan Road, Qingdao, 266003 China
Abstract: The rapid development of nanomaterials has provided wonderful opportunities for the creation of new pharmaceutical preparations. As a drug carrier, nanomaterials integrate multiple functions into itself, including target delivery, environmental response triggered, biocompatibility and so on. Chitosan (CS), a natural biological polysaccharides, is a well-known promising drug delivery vector for therapeutics and diagnostics, owing to its biocompatibility, biodegradable, low toxicity and structure-modifiable. CS and its derivatives have been developed into various pharmaceutical applications such as colon target drug delivery, mucosal delivery, cancer therapy and so on. This review article discusses different forms of nanomaterials for drug delivery by using various approaches for the preparation of chitosan derivatives or nanocomposites.
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