Special Issue "Bioceramics"
Deadline for manuscript submissions: closed (31 March 2015)
Prof. Andrew Ruys
Director of Biomedical Engineering,University of Sydney,Sydney, NSW, Australia
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Interests: biomaterials; bioceramics; ceramics; hydroxyapatite; alumina; ZTA (zirconia toughened alumina); DLC (diamond-like carbon); fibre-reinforced ceramics; porous materials; scaffolds; tissue engineering; bioactive glasses; electrophoretic deposition; bionic feedthroughs; bioactive coatings; DLC coatings; drug delivery
Bioceramics have come of age in the 21st century. Two unique and revolutionary areas stand out: tissue-bonding bioactivity, and ultra-wear-resistant bioinert bearings for joint prostheses.
Bioactivity, the capability of bonding to hard and soft tissue in vivo, is a property for which calcium phosphate bioceramics have been a strong research focus for some decades, both as polycrystalline calcium phosphate ceramics and as calcium phosphate silicate bioactive glass and glass ceramics, commonly referred to as bioglass. For some decades now, the direct bonding osteogenesis of hydroxyapatite with bone in vivo has been well known and developed commercially, primarily in bioactive coatings on metallic implants. Biodegradable calcium phosphates such as tricalcium phosphates are widely used in synthetic bone grafts. Bioactive glass is capable not only of bonding with bone in vivo, but certain compositions can even bond with soft tissues in vivo, giving rise to a new class of bioglass-doped polymer scaffolds and implants capable of soft-tissue bonding in vivo. The whole field of connective-tissue engineering is underpinned by scaffolds made from or doped with bioactive bioceramics. Many other issues are also important in the bioactivity of bioceramics, such as micro and nano topography, growth factors, and trace ion additives such as silicon magnesium and strontium.
Alumina-based bioceramics have revolutionised the hip replacement in the last decade with the rise of alumina and zirconia-toughened-alumina ceramics as the bearing components of hip joints from virtually non-existent a decade ago to now more than 50% of the global market, and rising rapidly. This is due to the Australian discovery (Ron Garvie 1972) of zirconia transformation toughening, and the discovery in the 1990s that tetragonal zirconia nanoparticles were stable in an alumina matrix in vivo. Not only are the ceramic wear rates hundreds of times lower than polymers and metals, the wear particles of alumina and zirconia are benign, unlike metallic wear particles which can be toxic, and polyethylene wear particles which are an irritant.
There are many other bioceramic technologies and applications. The field is rapidly advancing into new areas of discovery.
It is my pleasure to invite you to submit a manuscript for this Special Issue. Full papers, communications, and reviews are all welcome.Prof. Andrew Ruys
Manuscript Submission Information
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- calcium phosphate, hydrooxyapatite
- bioglass/bioactive glass
- alumina, zirconia, ZTA
- bone graft, scaffold